The convergence of wearable technologies and digital twin (DT) systems is transforming rehabilitation engineering, enabling continuous monitoring, personalized therapeutic interventions, and predictive modeling of patient recovery pathways. This review examines the growing role of machine learning (ML) in the development and integration of DTs frameworks in rehabilitation, with a focus on wearable sensor data, security and privacy, edge computing architectures, federated learning paradigms, and generative artificial intelligence (GenAI) applications. We first analyze data collection processes, emphasizing multimodal sensing, signal processing, and real-time synchronization between physical and virtual patient models. We then discuss key challenges related to data security, encryption, and privacy protection, especially in distributed clinical environments. The review then assesses the role of edge computing in reducing latency, improving energy efficiency, and enabling real-time local intelligence feedback in wearable devices. Federated learning approaches are discussed as promising strategies for jointly training ML models without compromising sensitive medical data. Finally, we present new GenAI techniques for generating synthetic data, personalizing digital twins, and simulating rehabilitation scenarios. By mapping current progress and identifying research gaps, this article provides a unified view that connects electronic and biomedical engineering with intelligent, secure, and adaptive DT ecosystems for next-generation rehabilitation solutions. Wearable devices with ML and DTs for rehabilitation are developing rapidly, but their current effectiveness still depends on consistent, high-quality data streams and robust clinical validation. The most promising convergence involves combining edge intelligence with federated learning to enable real-time personalization while preserving patient privacy. GenAI further enhances these systems by simulating patient-specific scenarios, accelerating model adaptation, and treatment planning. Key challenges remain related to standardizing data formats, ensuring comprehensive security, and seamlessly integrating these technologies into clinical processes.

Digital twins (DTs) powered by artificial intelligence (AI) are becoming important transformational tools in healthcare, enabling real-time simulation and personalized decision support at the patient level. The aim of this review is to critically examine the evolution, current applications, and future potential of AI-based DTs in healthcare, with a particular focus on their role in enabling real-time simulation and personalized patient-level decision support. Specifically, the review aims to provide a comprehensive overview of how AI-based DTs are being developed and implemented in various clinical domains, identifying existing scientific and technical gaps and highlighting methodological, regulatory, and ethical issues. Taking a “local to global” perspective, the review aims to explore how individual patient-level models can be scaled and integrated to inform population health strategies, global data networks, and collaborative research ecosystems. This will provide a structured foundation for future research, clinical applications, and policy development in this rapidly evolving field. Locally, DTs allow medical professionals to model individual patient physiology, predict disease progression, and optimize treatment strategies. Hospitals are implementing AI-based DT platforms to simulate workflows, efficiently allocate resources, and improve patient safety. Generative AI further enhances these applications by creating synthetic patient data for training, filling gaps in incomplete records, and enabling privacy-respecting research. On a broader scale, regional health systems can use connected DTs to model population health trends and predict responses to public health interventions. On a national scale, governments and policymakers can use these insights for strategic planning, resource allocation, and increasing resilience to health crises. Internationally and globally, AI-based DTs can integrate diverse datasets across borders to support research collaboration and improve early pandemic detection. Generative AI contributes to global efforts by harmonizing heterogeneous data, creating standardized virtual patient cohorts, and supporting cross-cultural medical education. Combining local precision with global insights highlights DTs’ role as a bridge between personalized and global health. Despite the efforts of medical and technical specialists, ethical, regulatory, and data governance challenges remain crucial to ensuring responsible and equitable implementation worldwide. In conclusion, AI-based DTs represent a transformative paradigm, combining individual patient care with systemic and global health management. These perspectives highlight the potential of AI-based DTs to bridge precision medicine and public health, provided ethical, regulatory, and governance challenges are addressed responsibly.

Cyber–physical systems (CPS) in healthcare represent a deep integration of computational intelligence, physical medical devices, and human-centric data, enabling continuous, adaptive, and personalized care. These systems combine real-time measurements, artificial intelligence (AI)-based analytics, and networked medical devices to monitor, predict, and optimize patient health outcomes. A key development in the field of CPS is the emergence of patient digital twins (DTs), virtual models of individual patients that simulate biological, behavioral, and social parameters. Using AI, DTs analyze complex medical and social data (genetics, lifestyle, environment, etc.) to support precise diagnosis and treatment planning. The implications of the bibliometric findings suggest that the field emerges from the conceptual phase, justifying the article’s emphasis on both the proposed architectures and their clinical validation. However, most research was conducted in computer science, engineering, and mathematics, rather than medicine and healthcare, suggesting an early stage of technological maturity. Leading countries were India, the United States, and China, but these countries did not have a high number of publications, nor did they record leading researchers or affiliations, suggesting significant research fragmentation. The most frequently observed Sustainable Development Goals indicate an industrial context. Reflecting insights from medical and social research, AI-based DT systems provide a holistic view of the patient, taking into account not only physiological states but also psychological and social well-being. These systems promote personalized therapy by dynamically adapting treatment based on real-time feedback from wearable sensors and electronic medical records. More broadly, CPS and DT systems increase healthcare system efficiency by reducing hospitalizations and supporting remote preventive care. Their implementation poses significant ethical and privacy challenges, particularly regarding data ownership, algorithm transparency, and patient autonomy.

Artificial intelligence (AI)-based digital twins (DTs) are emerging as a groundbreaking paradigm in rehabilitation and physiotherapy, enabling the creation of dynamic virtual representations of patients for continuous monitoring, prognostic assessment and personalised therapeutic interventions. This article presents a global, interdisciplinary review of AI-based DT technologies in rehabilitation settings utilising the Internet of Medical Things (IoMT), with particular emphasis on the integration of wearable and implantable sensor systems in next-generation wireless healthcare applications. The article analyses how multimodal wearable sensors, implantable devices and smart wireless communication networks can support the acquisition of real-time biomechanical and physiological data for adaptive rehabilitation. By combining perspectives from biomedical engineering, physiotherapy, computational intelligence and wireless healthcare systems, this article highlights the emerging opportunities and challenges associated with the creation of scalable digital twin ecosystems for precision rehabilitation. The proposed vision contributes to the development of smart, connected and personalized rehabilitation infrastructures, in line with future paradigms of healthcare and wireless communication.

This bibliometric study examines the role of ubiquitous computing and intelligent systems in the treatment of mental and neurological disorders. Ubiquitous computing integrates computational intelligence into everyday environments, enabling seamless monitoring and support of patients. Intelligent systems, including wearable devices, environmental sensors, and mobile health applications, collect real-time data on behavior, physiology, and environmental factors. These systems support early detection of symptom changes, adherence to treatment, and crisis prediction through context-aware analysis. Artificial intelligence (AI) processes the collected data to generate personalized therapeutic feedback and notify healthcare providers when intervention is needed. In mental health care, intelligent environments can monitor mood, sleep, and social interaction patterns, providing valuable objective information about mental health status. In the case of neurological conditions such as Parkinson’s disease or epilepsy, intelligent systems facilitate movement tracking, seizure detection, and cognitive assessment outside of the clinical setting. Integration with electronic health records and telemedicine platforms ensures coordinated and responsive care. Ethical design, privacy protection, and patient consent remain key to successful implementation. In this way, ubiquitous computing is transforming care models by increasing autonomy, precision, and continuity in the treatment of complex neurodegenerative diseases, including those related to neurodegeneration in aging.

Owing to current events in Belarus (political and social, including the economic crisis and the ongoing activities that are having a negative impact on the functioning of opposition movements), the country is becoming an arena of competition for influence. In the context of the subject of this analysis, rivalry, especially in terms of the influence of other states on Belarusian society, is of key importance. Science diplomacy may be a tool of competition for influence. The fact that science diplomacy can be both a tool with which to cooperate with other countries in the region and a tool of competition for influence is of key importance in analysing this problem. The scientific potential of the Belarusian community is also of interest to other countries, including Ukraine, Lithuania, and Germany. The effective and efficient implementation of science diplomacy activities towards Belarus is undoubtedly in line with the well-understood Polish national interest. The aim of the article was to conduct a political and legal analysis of the process by which Poland is using science diplomacy as a tool for influencing the scientific community of Belarus. Another research goal was to analyse the activities undertaken by two other countries in the region – Ukraine and Lithuania – with respect to science diplomacy. The article also aimed to analyse the formal and legal conditions related to the normative solutions used in the countries under analysis, enabling the undertaking and implementation of education by Belarusian citizens. The educational and scientific programmes offered to students and scientists from Belarus in Poland were also subject to legal analyses. The whole analysis is supplemented and concluded by an attempt to evaluate the effectiveness of the activities carried out so far.