Compound 3a showed excellent herbicidal activity against barnyard grass with IC ₅₀ = 7.0 mg L ⁻¹ , and exhibited good selection for rice, wheat, and radish at 100 mg L ⁻¹ .

In this study, a series of novel sec-p-menthane-7-amine derivatives were designed, synthesized, and evaluated to be used as efficient botanical herbicides owing to their post-emergence herbicidal activities against barnyard grass and rape.