Particle-bound pollutants are a critical risk factor for human respiratory/cardiovascular conditions. A comprehensive analysis of the physicochemical characteristics of PM is often challenging since it requires combining different practical methods with a good understanding the of characterization outputs. The present review aims to (1) provide a comprehensive assessment of the underlying mechanisms of PM cytotoxicity and the related biological response; (2) evaluate the selected methods for PM characterization in terms of outputs, technical aspects, challenges, and sample preparation; (3) present effective means of studying PM physicochemical toxicity and composition; and (4) provide recommendations for enhancing the human health risk assessment. The cellular response to potentially toxic elements in PM is complex to understand as exposure includes systemic inflammation, increased ROS accumulation, and oxidative stress. A comprehensive toxicity assessment requires blending morphological features and chemical composition data. For the morphological/chemical characterization, we recommend first using SEM-EDS as a practical method for the single-particle analysis. Then, the bulk chemistry of PM can be further studied using either a dry analysis (e.g., XRF) or wet analysis techniques (e.g., ICP and IC). Finally, when used on a need basis, the reviewed complementary laboratory methods may further add valuable information to the characterization. The accuracy of the human health risk assessment may be improved using bioaccessible/soluble fractions of the contaminants instead of the total contaminant concentration. Having an integrated understanding of the covered analytical methods along with the health risk assessment guidelines would contribute to research on atmospheric chemistry, molecular biology, and public health while helping researchers better characterize human exposure to PM and the associated adverse health effects.

The construction sector is a major contributor to global solid waste generation, with demolition waste posing substantial environmental and economic challenges. The present study introduces a demolition waste estimation tool and applies it to a rapidly transforming city: Astana, the capital of Kazakhstan. The approach is also readily applicable to cities in transformation with similar characteristics, e.g., those in the Commonwealth of Independent States region and beyond. The key materials of interest were identified as those that can be efficiently extracted from buildings slated for demolition. A comprehensive analysis of current building stocks and demolition plans (2023–2029) was then conducted. Based on the height, purpose, and main material of the building, the main types and subtypes of the building stock in Astana were created. The results for Astana showed that 67.52% or 1736.5 thousand tons of all demolition waste could be recovered. Concrete had the highest recovery potential by mass (162.42 thousand tons annually) and by percent (91%). The economic analysis of construction and demolition waste illustrated a financial potential from construction and demolition waste recovery in Astana at USD 4600 million per year, with concrete having the highest potential among fractions (56% of total).

Despite severe particulate matter (PM) pollution in Central Asia, limited air composition and health impact data are hindering sustainable air quality management and resilient urban planning. This study provides the first comprehensive assessment of PM_2.5 and PM_2.5–10 in the urban environment of Astana, Kazakhstan, a rapidly expanding city with intense winter heating demands. We characterized PM and atmospheric precipitation and assessed health risks using bioaccessible fractions of PM-bound potentially toxic elements (PTEs). Among 388 samples, PM_2.5 and PM_2.5–10 concentrations peaked at 534 and 1564 μg·m⁻³, respectively. Scanning electron microscopy (SEM) identified soot and coal fly ash, indicating fossil fuel combustion as a major source. Precipitation characterization also showed elevated SO₄²⁻ (17.8 μg⋅L⁻¹), V (108 μg⋅L⁻¹), Ni (84.0 μg⋅L⁻¹), and Mn (63.2 μg⋅L⁻¹). Bioaccessibility tests showed high solubility for Fe (16,229 mg·kg⁻¹) followed by V: key indicators of combustion emissions. Non-carcinogenic risk for Ni and V exceeded acceptable limits for adults and children (e.g., HQ: 6.07 for V for adults). Carcinogenic risk exceeded the threshold 10⁻⁶ for Cd (adults), Co, Cr, and Ni. These findings may help advance urban air quality management via integrating bioaccessibility-based health risk assessment and source apportionment, supporting evidence-driven policies for environmentally responsible development in rapidly urbanizing cold-climate regions.