The purpose of this study is to investigate the difference of change in the retinal nerve fiber layer (RNFL) and the ganglion cell complex (GCC) thickness according to age in glaucoma suspect individuals and healthy subjects. Thicknesses of RNFL and GCC were measured with spectral domain optical coherence tomography (SD-OCT) in glaucoma-suspected individuals and healthy subjects. The differences in age, overall mean, four quadrants, and 12 clock-hour sectors of RNFL and overall mean, superior half, and inferior half GCC thicknesses between glaucoma suspects and healthy participants were analyzed and compared using linear regression analyses. There were 201 glaucoma-suspect individuals and 121 healthy subjects with a mean age of 38.89 and 40.26 years, respectively (p = 0.27). The mean overall RNFL thickness was found to be 97.76 and 97.43 µm in healthy individuals and glaucoma suspects (p = 0.72). The mean overall GCC thickness was found to be 111.30 and 104.67 µm in healthy individuals and glaucoma suspects, respectively (p < 0.001). There was a 0.11 µm decrease per year found in overall GCC thickness in glaucoma suspects and 0.23 µm decreases per year in overall GCC thickness in healthy individuals (p < 0.001). There was a 0.02 µm decrease per year found in overall RNFL thickness in glaucoma suspects and a 0.29 µm decrease per year in overall RNFL thickness in healthy individuals (p < 0.001). However, these per-year decreases in GCC thickness glaucoma suspects and healthy individuals were not found to be statistically significant (p = 0.21); on the other hand, this difference for RNFL thickness was significant (p < 0.001). It was found that the thicknesses of RNFL and GCC were different between glaucoma suspects and healthy individuals. However, age-related decay in the RNFL and GCC thicknesses was not uniform in healthy individuals and glaucoma suspects. It was found that the RNFL thickness and GCC thickness were lower in glaucoma suspects than in healthy controls eyes. However, an age-related decrease of RNFL and GCC thicknesses were found to be less in glaucoma suspects compared with healthy controls. Firatli G, Elibol A, Altinbas E, et al. The Comparison of Age-related Change in Retinal Nerve Fiber Layer and Ganglion Cell Complex Thicknesses between Glaucoma Suspects and Healthy Individuals. J Curr Glaucoma Pract 2023;17(1):22-29.

PURPOSE Researchers are interested in examining the impact of visual display devices (VDDs) on the development of dry eye illness because their use is becoming more common among college students. The goal of this study was to see if there was a link between certain risk factors and the development of eye dryness in VDDs using young adults who wore contact lenses and those who didn't. METHODS The self-administrated survey was hosted in Google Forms, sent via e-mail to the participants. It consisted of two parts of assessing different risk factors (i.e. environmental conditions, angle of gaze, years of VDD use) with contact lens use and Ocular Surface Disease Index (OSDI) questionnaire. The OSDI scores of the entire sample who suffer from dry eye and the subgroup using contact lenses were calculated. The relationship between different risk factors with the OSDI scores was also assessed. RESULTS 274 young adults from college students and academic staff (216 female, 58 male) were suffering from eye dryness. 88 of the 274 participants wore contact lenses. The mean OSDI scores of the 274 young adults was 32.92. Mean OSDI scores in contact lens wearers and non-wearers were 34.36 and 32.24 respectively (p<0.01). There was a statistically significant relationship between OSDI score and indoor environmental conditions in computer using VDD group. Using a computer in a dark environment and above the line of sight resulted in a higher OSDI scores. Females who wore contact lenses whilst using a computer for more than three years had significantly higher OSDI scores than non-wearer females. Tablet type VDD use increased the mean ODSI scores of the contact lens wearers significantly. CONCLUSIONS Dry eye symptoms were shown to be increased in the contact lens wearer group with the increased duration of computer VDD use, decreased indoor environmental brightness conditions, and above the line of sight.

Background/Objectives: Intrahepatic cholestasis of pregnancy (ICP) is associated with adverse perinatal outcomes. However, its metabolic consequences on newborns remain inadequately characterized. This study investigated amino acid, carnitine, and acylcarnitine profiles in neonates born to mothers with ICP. Methods: This retrospective study encompassed 299 neonates born to mothers with ICP. For comparative analysis, term infants without additional complications (ICP-term, n = 150) were compared with term controls (n = 150). Capillary blood samples collected at 24–48 h of life as part of newborn screening were analyzed using LC–MS/MS for acylcarnitine and amino acid profiles. Results: The ICP cohort exhibited a high preterm delivery rate (46.2%), with maternal bile acids negatively correlating with gestational age (r = −0.266, p < 0.001). No inborn errors of metabolism were observed. Elevated levels of amino acids (alanine, leucine/isoleucine, valine, tyrosine, arginine, glycine, and ornithine) and specific acylcarnitines (C5, C5-OH, C10:1, and C18:2), along with decreased levels of amino acids (argininosuccinic acid and glutamic acid) and specific acylcarnitines (C3, C5-DC, C6-DC, C14, C14:1, C16, C16:1, and C18:1-OH), were observed in ICP-term neonates (p < 0.05). Receiver operating characteristic curve analysis identified ornithine (area under the curve [AUC] = 0.74) and leucine/isoleucine (AUC = 0.73) as strong discriminators. A multivariable model integrating multiple metabolites achieved high accuracy (AUC = 0.86 ± 0.03). Conclusions: This first comprehensive characterization of neonatal metabolic alterations in ICP reveals amino acid metabolism, fatty acid oxidation, and mitochondrial function disruptions, suggesting fetal adaptation to a cholestatic intrauterine environment. Metabolomic profiling may improve understanding of maternal–fetal interactions and inform strategies for risk stratification and long-term monitoring.

Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction (SCAR) typically characterized by sterile pustules. The bullous variant of AGEP is exceptionally rare and represents a significant diagnostic challenge as it clinically mimics toxic epidermal necrolysis (TEN). We report the case of a 91‐year‐old woman who developed AGEP following moxifloxacin therapy, which rapidly progressed into a bullous form. A striking and rarely described clinical phenomenon—pustules developing directly on the roof of flaccid bullae—was observed. To our knowledge, this is the first reported case of the bullous variant of AGEP specifically triggered by moxifloxacin. Despite intensive treatment, the patient succumbed to sepsis on Day 15. This case underscores the importance of recognizing atypical AGEP presentations to avoid diagnostic confusion with Stevens–Johnson syndrome (SJS)/TEN and highlights a novel severe reaction to a widely used fluoroquinolone.