A new coronavirus disease began on 31 December 2019 in Wuhan/China and has caused a global outbreak in only a few months resulting in millions being infected. In conjunction with its’ physical side effects, this outbreak also has a tremendous impact on psychology health. This study aims to assess the spread and frequency of protective behaviors, emotional and anxiety status among the Turkish population using a rapid survey during the COVID-19 outbreak. An online questionnaire was administered to 3,040 respondents between the ages of 18–30. This cross-sectional study was conducted from Apr 2 to Apr 8, 2020. While questions related to the outbreak were created by members of our neuroscience department, the Turkish version of the Abbreviated Beck Anxiety Inventory was included in our survey to measure anxiety status. Pearson correlation coefficient was used for statistical analysis. We found that 90% of respondents report washing hands more frequently since the outbreak while %50 wear protective gloves. Respondents were more fearful of their relatives catching the coronavirus disease than they were of themselves catching it. In response to the question, “What are your emotions about the coronavirus?”, 38% responded with “worried”. There was a significant correlation between anxiety status and consumption information from the media about COVID-19. Individual early protection behaviors might slow transmission of the outbreak. Our results showed that the behavior of the participants has changed in predictable ways during the COVID-19 outbreak. Understanding how emotional responses such as fear and anxiety status vary and the specific factors that mediate it may help with the design of outbreak control strategies.

Objectives: Pareidolia is the interpretation of previously unseen and unrelated objects as familiar due to previous learning. The present study aimed to determine the specific brain areas that exhibited activation during real-face and face-pareidolia processing.Methods: Functional Magnetic Resonance Imaging (fMRI) scans were performed on 20 healthy subjects under real-face and face-pareidolia conditions in National Magnetic Resonance Research Center (UMRAM), Ankara, Turkey from April 2016 to January 2017. FSL software was used to conduct a FEAT higher level (group) analysis to identify the brain areas activated during real-face and face-pareidolia processing.Results: Under both the real-face and face-pareidolia conditions, activation was observed in the Prefrontal Cortex (PFCX), occipital cortex V1, occipital cortex V2, and inferior temporal regions. Also under both conditions, the same degree of activation was observed in the right Fusiform Face Area (FFA) and the right PFCX. On the other hand, PFCX activation was not evident under the real-face versus face scrambled or face-pareidolia versus pareidolia scrambled conditions.Conclusions: The present findings suggest that, as in real-face perception, face-pareidolia requires interaction between top-down and bottom-up brain regions including the FFA and frontal and occipitotemporal areas. Additionally, whole-brain analyses revealed that the right PFCX played an important role in processing real faces and in face pareidolia (illusory face perception), as did the FFA.doi: https://doi.org/10.12669/pjms.346.16140How to cite this:Akdeniz G, Toker S, Atli I. Neural mechanisms underlying visual pareidolia processing: An fMRI study. Pak J Med Sci. 2018;34(6):1560-1566.

Background: Few studies have been conducted that have compared electrical source localization (ESL) results obtained by analyzing ictal patterns in scalp electroencephalogram (EEG) with the brain areas that are found to be responsible for seizures using other brain imaging techniques. Additionally, adequate studies have not been performed to confirm the accuracy of ESL methods. Materials and Methods: In this study, ESL was conducted using LORETA (Low Resolution Brain Electromagnetic Tomography) in 9 patients with lesions apparent on magnetic resonance imaging (MRI) and in 6 patients who did not exhibit lesions on their MRIs. EEGs of patients who underwent surgery for epilepsy and had follow-ups for at least 1 year after operations were analyzed for ictal spike, rhythmic, paroxysmal fast, and obscured EEG activities. Epileptogenic zones identified in postoperative MRIs were then compared with localizations obtained by LORETA model we employed. Results: We found that brain areas determined via ESL were in concordance with resected brain areas for 13 of the 15 patients evaluated, and those 13 patients were post-operatively determined as being seizure-free. Conclusion: ESL, which is a noninvasive technique, may contribute to the correct delineation of epileptogenic zones in patients who will eventually undergo surgery to treat epilepsy, (regardless of neuroimaging status). Moreover, ESL may aid in deciding on the number and localization of intracranial electrodes to be used in patients who are candidates for invasive recording.

Objective: The aim of this study was to evaluate dynamic thiol-disulphide homeostasis as a novel oxidative stress parameter in patients with Guillain-Barre syndrome (GBS). Methods: A total of 130 participants were included in this study, 70 of whom were diagnosed with GBS. Total thiol (-SH+-S-S-) and native thiol (-SH) levels in serum were measured in all patients and healthy individuals. Amount of dynamic disulphide bond were calculated from these values. In the GBS patients, disability status was determined by the Hughes and Medical Research Center (MRC) sum scores at the time of admission and 3 months thereafter. Results: Total and native thiol levels were significantly lower in patients with GBS compared with healthy individuals. There was no statistically significant difference in the number of dynamic disulphide bonds between groups. There was a negative correlation between total thiol levels in patients with GBS and Hughes scores at month 3. Discussion: Oxidative stress is among the molecular changes underlying the pathogenesis of GBS. In this study, we have investigated the dynamic thiol-disulfide homeostasis in patients with epilepsy using a new method in the literature. Also, functional recovery in Guillain-Barré syndrome patients could be promoted by increasing antioxidant activity.