Skin aging involves oxidative stress, inflammation, and hyperpigmentation, prompting growing interest in plant-based treatments. Pistacia lentiscus L. and Pistacia atlantica Desf. (Anacardiaceae), North African pharmacopoeia species with recognized phytotherapeutic and cosmeceutical properties, were analyzed to elucidate these biological activities through their phytochemical composition and in vitro antioxidant, anti-inflammatory, and anti-hyperpigmentation potentials. Leaves were successively extracted with hexane, ethyl acetate, and methanol. The methanolic leaf extract of P. atlantica exhibited the highest total phenolic content (430.28 ± 0.01 mg GAE/g), while P. lentiscus showed the highest flavonoid content (230.00 ± 0.01 mg QE/g). LC–MS/MS analysis identified thirteen major phenolic compounds, including methyl gallate and myricitrin. Biological assays revealed that P. lentiscus exhibited the strongest antioxidant activity (IC₅₀ = 5.19 ± 0.01 µg/mL) and the highest ferric-reducing power, whereas P. atlantica showed strong inhibition of protein denaturation (139.10 ± 0.55 µg/mL). Both extracts displayed potent anti-lipoxygenase activity (IC₅₀ = 22.53 ± 0.05 and 22.67 ± 0.04 µg/mL, respectively), as well as anti-tyrosinase effects (IC₅₀ = 39.80 ± 0.08 and 38.25 ± 0.02 µg/mL, respectively). Altogether, these findings underscore the cosmetic potential of these Pistacia species and support their use as valuable raw materials for the development of dermatological treatments.

From seed dormancy to pathogen attacks and senescence, many events in a plant's life are critically controlled by low‐molecular‐weight signaling molecules, called plant hormones. These master regulators include abscisic acid, auxins, brassinosteroids, cytokinins, ethylene, gibberellins, jasmonates, salicylates, and strigolactones. Years of research have unveiled multiple aspects of their biosynthesis, transport, signaling, functions, and interactions. With this knowledge, complex molecular networks have been established and refined over time in an attempt to explain how plant hormones collectively mediate physiological processes, under a wide range of contexts and at various developmental stages. In this context, we aim to shed light on the global molecular framework of plant hormonal signaling. To do so, we first step back and offer a deconvolution of plant hormonal pathways, by addressing their biosynthesis, transport, and signaling. We then explore how hormonal pathways interfere with each other at a molecular level, mostly through transcriptional regulation and protein–protein interactions. We further discuss directions to fine‐tune our fundamental understanding of plant hormonal control, and finally, we highlight how this knowledge can be translated into applied prospects to tackle unprecedented agricultural challenges.