Atopic dermatitis (AD) is characterized by chronic, relapsing, pruritic skin inflammation and does not have a well-understood pathogenesis. In this study, we addressed the contribution of adipokines to AD eczema based on the assessment of blood levels of adiponectin, resistin, leptin, lipocalin-2, and vaspin in adult non-obese patients suffering from chronic extrinsic childhood-onset AD. We investigated 49 AD patients with a median age of 37 years. The control group consisted of 30 age-matched healthy subjects. Adipokines were assessed in the serum by ELISA assays and the severity of AD with the SCORing Atopic Dermatitis (SCORAD) index. We found that adiponectin and resistin decreased and leptin appreciably increased in AD patients when compared to those in healthy subjects. Further, the levels of adiponectin and resistin were inversely related to the intensity of eczema. In conclusion, apart from the formerly investigated role of leptin in AD, this study points to adiponectin and resistin as the potential candidate adipokine biomarkers involved in shaping eczema intensity and severity, which may help predict disease exacerbations and enable the development of effective targeted therapeutic interventions.

Objectives: The recovery of arm function after macroreplantation is influenced by various factors. The aim of this study was to present the results of functional rehabilitation outcome after replantation of an upper extremity. Moreover, we assessed nerve conduction validity in the process of monitoring the return of manual functions. Methods: The study was performed in a group of seven patients after upper extremity macroreplantation and rehabilitation. Assessments included measuring hand/arm function loss using Swanson’s method, range of motion, muscle strength, sensation, and manipulation dexterity through the NHPT (Nine-Hole Peg Test). The nerve conduction study measured response amplitude, conduction speed, and distal latency. Results: The average loss of function of the hand diminished from 63.6% to 49.18%. Significant improvement in global pressure was achieved. In the functional capacity test (NHPT), the average time of the test was improved. The final nerve conduction study demonstrated improvements in motor and sensory conduction parameters. A correlation between improvement in conduction parameters in sensory fibers and sensation in the two-point discrimination test was found. Increased potential amplitude in motor fibers of the examined nerves correlated with a decrease in loss of function of the arm. Conclusions: Functional assessment and tailored rehabilitation strategies would maximize recovery potential after macroreplantation. Nerve conduction remains a crucial tool in monitoring the progress of manual skills after months of rehabilitation. Our findings highlight the importance of long-term follow-up of these patients.

Atopic dermatitis is a chronic recurrent skin disease characterised by itching and eczematous skin lesions. The paper presents the case of a 62-year-old female patient suffering from atopic dermatitis, in whom symptoms were observed within the nail apparatus of the hand, including red rings, Beau lines, lack of cuticle and lichenification with erosions, cracks, scabs, and residual blisters on the backs of the hands. The patient experienced severe itching, which led to increased manipulations within the nail apparatus (onychotillomania), which was reflected in the presence of the so-called tare nails. The patient’s treatment included the use of topical medications, including clobetasol propionate, mometasone, and tacrolimus 0.1%, as well as intensive hand lubrication and the use of specialised hand cleansers. Intensification of mental health care was also recommended. The presented case highlights the importance of a comprehensive approach to the treatment of atopic dermatitis, especially in the era of new therapeutic methods.