Early diagnosis of cancer can significantly contribute to improving therapeutic outcomes and enhancing survival rates for cancer patients. Polymer-based biosensors have emerged as a promising tool for cancer detection due to their high sensitivity, selectivity, and low cost. These biosensors utilize functionalized polymers in different parts of the body to detect cancer biomarkers in biological samples. This approach offers several advantages over traditional detection methods, including real-time monitoring and noninvasive detection while maintaining high sensitivity and accuracy. This review discusses recent advances in the development of polymer-based biosensors for cancer detection including their design, fabrication, and performance. The essential characteristics of biosensing devices are presented, along with examples for natural and synthetic polymers commonly utilized in biosensors. Furthermore, strategies employed to tailor polymers to improve biosensing applications and future perspectives for the application of polymer-based biosensors in cancer diagnosis are also highlighted. Integrating these advancements will illuminate the potential of polymer-based biosensors as transformative tools in the early detection and management of cancer.

The self-gelation utilizes natural vanillin as a primary component of vanilla bean extract, and as a crosslinking agent for entangling chitosan–PVA hydrogels. This involves a Schiff-base reaction, where amino group of chitosan (CH) interacts with aldehyde group of vanillin (Van). The optimized formula of formed hydrogels is chosen based on achieving a well-balanced combination of self-healing capability, mechanical strength, sustained release profile, and hydrophilic tendency. The prepared hydrogel is thoroughly characterized using SEM and FTIR analyses, swelling ratio, hydrolytic rate assessment, and in vitro drug release profiling. CH–PVA–Van hydrogels demonstrate controlled drug release that is sustained for over 7 days. Furthermore, antimicrobial tests indicate strong activity of CH–PVA–Van–L-arginine against Gram-positive bacteria, compared to tested yeast or Gram-negative bacteria using multiple human pathogens. Subsequently, in vitro biological assays are conducted to confirm the effectiveness of the prepared hydrogel in promoting wound healing and bone regeneration through cytotoxicity assay and wound scratch assay. The composite hydrogels achieved 95% wound healing after 24 hours, attributed to the release of NO from the loaded L-Arg and its essential role in the wound healing process. Consequently, CH–PVA–Van hydrogels emerge as a promising system for loading L-arginine and exhibiting potential for biomedical applications with antibacterial efficacy.

Green nanotechnology utilizes the principles of green chemistry to formulate eco-friendly nanocarrier systems to mitigate patients and environment hazards. Raloxifene (RLX) demonstrates poor aqueous solubility (BCS class II) and low bioavailability, only 2% (extensive first-pass metabolism). The aim of this study is to enhance RLX solubility and bioavailability via development of novel solid dispersed multilayered core-sheath RLX-loaded nanofibers (RLX-NFs) without the involvement of organic solvents. A modified emulsion electrospinning technique was developed. Electrospinning of an RLX-nanoemulsion (RLX-NE) with polymer solution (poly vinyl alcohol (PVA), hydroxypropyl methylcellulose (HPMC), and chitosan (CS) in different volume ratios (1:9, 2:8, and 4:6) using D-optimal response surface methodology was adopted. In vitro characterization of RLX-loaded NFs was performed; scanning electron microscope (SEM), thermal analysis, drug content, release studies, and bioadhesion potential. The optimum NFs formula was evaluated for morphology using high-resolution transmission electron microscopy (HRTEM), and ex vivo drug permeation. The superiority of E2 (comprising RLX-NE and PVA (2:8)) over other NF formulae was statistically observed with respect to Q60 (56.048%), Q240 (94.612%), fiber size (594.678 nm), mucoadhesion time 24 h, flux (5.51 µg/cm²/h), and enhancement ratio (2.12). RLX pharmacokinetics parameters were evaluated in rabbits following buccal application of NF formula E2, relative to RLX oral dispersion. E2 showed significantly higher Cmax (53.18 ± 4.56 ng/mL), and relative bioavailability (≈2.29-fold).