Gianfranco Morreale

Dr. Gianfranco Morreale


Research Focus & Metrics

Academic Career Length

2Years (2025-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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4 November 2025 in Preprints.org
Verified
Preprint
Open access
PDF file
FCFrancesco Giuseppe Cannone
Francesco Giuseppe Cannone
GMGianfranco Morreale
Gianfranco Morreale
MBMartina Billeci
Martina Billeci
Ferdinando Antonio GulinoFerdinando Antonio Gulino
Ferdinando Antonio Gulino
Uterine fibroids are among the most common benign tumors affecting women of reproductive age. Traditional treatment has often involved surgical removal, including hysterectomy, but minimally invasive alternatives such as radiofrequency ablation (RFA) have emerged. We report the case of a 41-year-old woman with symptomatic uterine fibroids (FIGO type 2–5, size of 5 cm) treated with transvaginal RFA. One month post-treatment, the fibroid showed partial volume reduction. Two months after the procedure, the patient presented with foul-smelling discharge and heavy bleeding. Ultrasound confirmed complete fibroid migration into the cervical canal. Vaginal removal was performed without complications. This case highlights a rare but notable outcome of RFA treatment. Transvaginal fibroid expulsion may be viewed as either a treatment-related complication or a spontaneous therapeutic result. To our knowledge, only one other case has been reported in the literature. Further studies are needed to assess the prognostic and clinical significance of this occurrence.

6 May 2026 in Reports
Verified
Journal Article
Open access
PDF file
FCFrancesco Cannone
Francesco Cannone
GMGianfranco Morreale
Gianfranco Morreale
MBMartina Billeci
Martina Billeci
Ferdinando Antonio GulinoFerdinando Antonio Gulino
Ferdinando Antonio Gulino
Uterine fibroids are among the most common benign tumors affecting women, with a prevalence reaching up to 50–60% in those over 40 years of age, although often underestimated due to asymptomatic cases. Radiofrequency ablation (RFA) represents a minimally invasive alternative to surgery for selected patients. We report the case of a 41-year-old woman with symptomatic uterine fibroids (FIGO type 4, size of 5 cm) treated with transvaginal RFA. One month post- treatment, the fibroid showed partial volume reduction. Two months after the procedure, the patient presented with foul-smelling discharge and heavy bleeding. Ultrasound confirmed complete fibroid migration into the cervical canal. Vaginal removal was performed without complications. Fibroid expulsion after RFA is a rare event that may represent either a complication or a therapeutic outcome. A balanced interpretation and appropriate clinical management are required. Further studies are needed to clarify its clinical significance.

14 December 2025 in Reports
Verified
Journal Article
Open access
PDF file
MBMartina Billeci
Martina Billeci
GMGianfranco Morreale
Gianfranco Morreale
Ferdinando Antonio GulinoFerdinando Antonio Gulino
Ferdinando Antonio Gulino
FCFrancesco Giuseppe Cannone
Francesco Giuseppe Cannone
Inferior vena cava (IVC) disruption with continuation of the azygos is a rare congenital vascular abnormality that can be detected prenatally via high-resolution ultrasound. We present a case of isolated discontinuation of IVC, diagnosed during a routine abnormal scan of the second trimester, confirmed by fetal echocardiography, with an uneventful neonatal outcome. In accordance with the literature, we discuss the diagnostic approach, clinical significance and long-term implications of this vascular variant. We want to emphasize the importance of recognizing this anomaly and differentiating isolated cases from those associated with other congenital malformations.