Ion-adsorption type rare earth element (IREE) deposits are critical strategic resources formed under strong lithological, geomorphological, and weathering controls. In Houaphanh Province, Laos, widespread granitic intrusions and tropical monsoon weathering provide favorable conditions for IREE mineralization; however, exploration is limited by rugged terrain, dense vegetation cover, and sparse geological data. This study integrates Landsat 9, ASTER multispectral, and digital elevation data to enhance IREE exploration. Band ratio and principal component analysis (PCA) were applied to extract lithological and alteration features, while six topographic parameters describing elevation, slope, relief amplitude, incision depth, surface roughness, and elevation variability were derived from ASTER GDEM data. These datasets were combined using a weighted overlay to delineate favorable geomorphic zones. Six prospectives zones were identified, and field verification at Nongkhang confirmed 19 IREE ore bodies. The results demonstrate that integrating spectral and topographic indicators significantly improves the accuracy for IREE prediction in tropical, densely vegetated regions, offering a transferable framework for similar geological settings worldwide.