Background: It is well-known that rotating shift work disrupts the circadian rhythm and sleep quality in nurses. With this study, we aimed to compare subjectively and objectively measured sleep quality in nurses, specifically focusing on any differences that arose in relation to shift work. Methods: This prospective, observational, cross-sectional study was conducted in 2025 in Croatia; a total of 140 nurses participated. Sleep was assessed using the Pittsburgh Sleep Quality Index (PSQI) and FitBit Charge 3 smartwatch, which monitored sleep over an eight-day period. Results: Most nurses rated their sleep as good or very good, but according to the PSQI questionnaire, all participants were classified as poor sleepers (PSQI > 5). Objective smartwatch measurements showed that nurses working only day shifts had higher sleep scores (median 77, IQR 75–80 vs. 73, IQR 68–76; p < 0.001), significantly longer total sleep duration (median 6.4, IQR 6.3–7.1 vs. 5.5, IQR 5.2–6.2 h; p < 0.001), and longer durations of all sleep stages compared with those working rotating shifts. Conclusions: Most nurses subjectively rated their sleep as good or very good; however, according to the PSQI questionnaire results, all were classified as poor sleepers, with no significant difference related to shift work. Objective measurements using the smartwatch indicated that rotating shift work is associated with significantly poorer sleep quality.

Novija saznanja i karakterizacija molekularne strukture alergenskih izvora koji su odgovorni za alergijsku senzitizaciju pridonijeli su etiološkom i individualno prilagođenom liječenju i nadzoru alergijskih bolesti. Molekularna alergologija omogućila...

Inborn errors of immunity represent a heterogeneous group of monogenic hereditary disorders resulting from impaired development or function of the immune system. Although rare as individual entities, their cumulative prevalence is estimated at 1:1,000 to 1:5,000. Clinically, these conditions are characterized by severe, recurrent, and antibiotic-resistant infections, frequently involving opportunistic pathogens. The incidence and spectrum of such infections are influenced by exposure to pathogens, which is shaped by factors such as universal vaccination programs and global health events, including the recent coronavirus disease pandemic. Beyond infectious complications, affected individuals frequently present with non-infectious manifestations, such as autoimmune, autoinflammatory, allergic, and malignant disorders, therefore broadening the clinical phenotype. Recognition of warning signs of inborn errors of the immune system is essential for pediatric healthcare providers, who are often the first to initiate immunological evaluation. Upon establishing clinical and laboratory suspicion, timely referral to tertiary centers is warranted. Early diagnosis and targeted intervention significantly reduce morbidity and complications and improve treatment outcomes in patients with congenital immunodeficiencies.