Dr. Peng Dayong

Co-authors

Following

Followers

Research Focus & Metrics

Explore full metrics on Scilit

Academic Career Length

13Years (2014-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications

27 December 2022 in Journal of Molecular Structure

Journal Article

Design, synthesis and antifungal activity of novel pyrazole amides derivates

Zhong Liang

Zeng Rong

Huang Cong

Ding Qing-Ying

Shi Ming-Zhu

Peng Dayong

1 January 2020 in Journal of Enzyme Inhibition and Medicinal Chemistry

Journal Article

Synthesis,in vitroinhibitory activity, kinetic study and molecular docking of novelN-alkyl–deoxynojirimycin derivatives as potential α-glucosidase inhibitors

Ping Lin

Jia-Cheng Zeng

Ji-Guang Chen

Xu-Liang Nie

En Yuan

Zhongping Yin

A series of novel N-alkyl-1-deoxynojirimycin derivatives 25 ∼ 44 were synthesised and evaluated for their in vitro α-glucosidase inhibitory activity to develop α-glucosidase inhibitors with high activity. All twenty compounds exhibited α-glucosidase inhibitory activity with IC₅₀ values ranging from 30.0 ± 0.6 µM to 2000 µM as compared to standard acarbose (IC₅₀ = 822.0 ± 1.5 µM). The most active compound 43 was ∼27-fold more active than acarbose. Kinetic study revealed that compounds 43, 40, and 34 were all competitive inhibitors on α-glucosidase with K_i of 10 µM, 52 µM, and 150 µM, respectively. Molecular docking demonstrated that the high active inhibitors interacted with α-glucosidase by four types of interactions, including hydrogen bonds, π–π stacking interactions, hydrophobic interactions, and electrostatic interaction. Among all the interactions, the π–π stacking interaction and hydrogen bond played a significant role in a various range of activities of the compounds.

14 August 2023 in Crystals

Journal Article

Synthesis, Crystal Structure, and Antifungal Activity of Quinazolinone Derivatives

In this paper, four new compounds with quinazolinone structure were designed and synthesized based on the special biological activity of quinazolinone. The four new compounds containing quinazolinone structures were synthesized using a one-pot method after intramolecular cyclization and dehydration catalyzed by aqueous methylamine solution. Their structures were characterized using ¹H NMR, ¹³C NMR, FT-IR, and HRMS, and the crystal structure of 2a was characterized using X-ray diffraction. In their potential antifungal activity tests, it was found that the four newly synthesized compounds exhibited significant antifungal activity against all seven phytopathogenic fungi at concentrations of 150 and 300 mg/L. Among them, the target compound 2c showed the best inhibitory effect against Fusarium oxysporum f. sp. Niveum fungus, with 62.42% inhibition at a concentration of 300 mg/L. Compound 2c is expected to be a leading compound for the treatment of watermelon Fusarium wilt in the future, which is worth further study.

26 March 2022 in Molecules

Journal Article

Design, Synthesis and Bioactivity Evaluation of Coumarin–BMT Hybrids as New Acetylcholinesterase Inhibitors

Coumarin possesses the aromatic group and showed plentiful activities, such as antioxidant, preventing asthma and antisepsis. In addition, coumarin derivatives usually possess good solubility, low cytotoxicity and excellent cell permeability. In our study, we synthesized the compound bridge methylene tacrine (BMT), which has the classical pharmacophore structure of Tacrine (THA). Based on the principle of active substructure splicing, BMT was used as a lead compound and synthesized coumarin–BMT hybrids by introducing coumarin to BMT. In this work, 21 novel hybrids of BMT and coumarin were synthesized and evaluated for their inhibitory activity on AChE. All obtained compounds present preferable inhibition. Compound 8b was the most active compound, with the value of K_i as 49.2 nM, which was higher than Galantamine (GAL) and lower than THA. The result of molecular docking showed that the highest binding free energy was −40.43 kcal/mol for compound 8b, which was an identical trend with the calculated K_i.

11 September 2019 in Molecules

Journal Article

Design, Synthesis, and Activity Evaluation of Novel N-benzyl Deoxynojirimycin Derivatives for Use as α-Glucosidase Inhibitors

To obtain α-glucosidase inhibitors with high activity, 19 NB-DNJDs (N-benzyl-deoxynojirimycin derivatives) were designed and synthesized. The results indicated that the 19 NB-DNJDs displayed different inhibitory activities towards α-glucosidase in vitro. Compound 18a (1-(4-hydroxy-3-methoxybenzyl)-2-(hydroxymethyl) piperidine-3,4,5-triol) showed the highest activity, with an IC₅₀ value of 0.207 ± 0.11 mM, followed by 18b (1-(3-bromo-4-hydroxy-5-methoxybenzyl)-2-(hydroxymethyl) piperidine-3,4,5-triol, IC₅₀: 0.276 ± 0.13 mM). Both IC₅₀ values of 18a and 18b were significantly lower than that of acarbose (IC₅₀: 0.353 ± 0.09 mM). According to the structure-activity analysis, substitution of the benzyl and bromine groups on the benzene ring decreased the inhibition activity, while methoxy and hydroxyl group substitution increased the activity, especially with the hydroxyl group substitution. Molecular docking results showed that three hydrogen bonds were formed between compound 18a and amino acids in the active site of α-glucosidase. Additionally, an arene–arene interaction was also modelled between the phenyl ring of compound 18a and Arg 315. The three hydrogen bonds and the arene–arene interaction resulted in a low binding energy (−5.8 kcal/mol) and gave 18a a higher inhibition activity. Consequently, compound 18a is a promising candidate as a new α-glucosidase inhibitor for the treatment of type Ⅱ diabetes.

5 May 2015 in Inflammation

Journal Article

TIM-3 Genetic Variations Affect Susceptibility to Osteoarthritis by Interfering with Interferon Gamma in CD4+ T Cells

Yanjun Ren

Shiying Shan

About Me

Da-yong Peng is based at the College of Chemistry and Materials, East China Woody Fragrance and Flavor Engineering Research Center of National Forestry and Grassland Administration, Jiangxi Agricultural University, Nanchang，330045, China. Research direction includes the design and synthesis of agricultural chemicals. 2009.09-2012.12 Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Graduate student/Doctor Papers published include: [1]Wan-Qiang Wang, Zhi-Qin Wang, Wei Sang, Rui Zhang , Hua Cheng*, Cheng Chen*, Da-Yong Peng*. Dehydrogenative amide synthesis from alcohols and amines utilizing N-heterocyclic carbene-based ruthenium complexes as efficient catalysts: The influence of catalyst loadings, ancillary and added ligands. Polyhedron,195 (2021) 114979. [2]Ping Lin, Jia-Cheng Zeng, Ji-Guang Chen, Xu-Liang Nie, En Yuan, Xiao-Qiang Wang, Da-Yong Peng* and Zhong-Ping Yin*. Synthesis, in vitro inhibitory activity, kinetic study and molecular docking of novel N-alkyl–deoxynojirimycin derivatives as potential α-glucosidase inhibitors, Journal of Enzyme Inhibition and Medicinal Chemistry, 2020,35(1): 1879-1890. [3] Qiufei Hou, Jiajie Wu , Jiemei Liang, Hongfu Liu, Yuqing He, Rui Zhang, Hua Cheng, *, Cheng Chen,* and Dayong Peng*. Synthesis and Photoluminescence Behavior of π-Conjugated 3-Substituted Isoquinoline Derivatives. Current Organic Chemistry, 2020, 24, 1517-1526.

Dr. Peng Dayong

Dr. Peng Dayong

Research Focus & Metrics

Academic Career Length

Publication Type Breakdown

Representative Publications

About Me