Burkitt lymphoma (BL) is a form of B-cell malignancy that progresses aggressively and is most often seen in children. While Epstein–Barr virus (EBV) is a double-stranded DNA virus that has been linked to a variety of cancers, it can transform B lymphocytes into immortalized cells, as shown in BL. Therefore, the estimated prevalence of EBV in a population may assist in the prediction of whether this population has a high risk of increased BL cases. This systematic review and meta-analysis aimed to estimate the prevalence of Epstein–Barr virus in patients with Burkitt lymphoma. Using the appropriate keywords, four electronic databases were searched. The quality of the included studies was assessed using the Joanna Briggs Institute’s critical appraisal tool. The results were reported as percentages with a 95% confidence interval using a random-effects model (CI). PROSPERO was used to register the protocol (CRD42022372293), and 135 studies were included. The prevalence of Epstein–Barr virus in patients with Burkitt lymphoma was 57.5% (95% CI: 51.5 to 63.4, n = 4837). The sensitivity analyses demonstrated consistent results, and 65.2% of studies were of high quality. Egger’s test revealed that there was a significant publication bias. EBV was found in a significantly high proportion of BL patients (more than 50% of BL patients). This study recommends EBV testing as an alternative for predictions and the assessment of the clinical disease status of BL.

Introduction: Smoking and the use of electronic cigarettes (e-cigs) are common practices that have significant consequences for oral health. Although the negative impact of traditional tobacco products on oral tissues is widely known, the emergence of e-cigs poses a new obstacle. This review summarises existing data on the influence of e-cigs on oral health, with a specific emphasis on dental caries and pro-inflammatory agents.Methods: A comprehensive search was conducted via PubMed, Web of Science, Embase, and Scopus to identify relevant studies published until September 2024. The structured search strategy uncovered 42 articles that were read in full text. The included articles consisted of clinical trials, observational studies, and laboratory investigations that examined the impact of e-cig aerosol on oral bacteria and pro-inflammatory markers and its potential to contribute to dental caries.Results: The findings indicate that e-cig users may have a higher prevalence of dental caries compared with non-smokers. Most studies focusing on bacteria showed that vaping may inhibit normal flora, giving cariogenic bacteria a chance to grow more. This finding indicates a notable oral health risk associated with vaping. Meta-analyses suggest no effect of using e-cigs on the levels of TNF-α, IL-1β, IL-6, and IL-8 in saliva, even if it may affect their levels in GCF. However, in GCF, only one study reported TNF-α and IL-1β, and only two studies reported IL-6 and IL-8. Nevertheless, the effects of e-cigs on dental caries require further investigation since the data do not provide a clear picture.Discussion: This review emphasises the necessity for ongoing research to clarify the mechanisms that cause these consequences and to guide public health policies aimed at reducing the harm caused by e-cigarettes.Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024537910, PROSPERO (CRD42024537910).

Aims. This study aimed to evaluate the clinical practices of local anesthesia in children. The study also sought to investigate pediatric dentists’ views on articaine infiltration anesthesia and their willingness to use it to replace the inferior dental nerve block in primary molars. Materials and Methods. A cross‐sectional survey was emailed to 183 registered specialists. Descriptive statistics along with chi‐square and Fisher’s exact tests were used for data analysis. Results. A total of 72 responses were received. The sample consisted of 62 (86.1%) females and 10 (13.8%) males with varying levels of experience. The vast majority of respondents (98.6%) used topical anesthesia in their practice with children. The most frequently used anesthetic agent was 2% lidocaine (72.2%) followed by 4% articaine (54.2%). The entire sample indicated that they frequently find difficulties in dose calculation for their child patient. Gender and level of experience did not significantly influence specialists’ practice or their knowledge of local anesthesia. More than a third (31.9%) of participants were not happy to replace the block anesthesia with articaine infiltration for the treatment of lower primary molars. The most indicated reasons for this unwillingness were lack of effectiveness (11%) and inadequate scientific evidence (11%). Conclusion. Most pediatric dentists used topical anesthesia with children. Lidocaine was the most commonly used injectable local anesthesia. Specialists’ current practices of local anesthesia in children generally conformed well to good standards. However, inadequate knowledge regarding dose calculation was revealed. In addition, specialists’ reluctance to use articaine infiltration instead of the block anesthesia was evident in the current population. Further studies, with larger sample size are encouraged.

The aim of this study was to assess the differences, if any, between general dental practitioners (GDPs) and endodontists, in the diagnosis and treatment of endodontic emergencies during the worldwide outbreak of COVID-19. An online questionnaire was randomly sent by social media to clinicians in different countries from 24 April, 2020 to May 4, 2020. The survey consisted of a series of questions about demographic characteristics, endodontic emergency diagnoses, approaches to prevent aerosol formation, drug prescriptions in case of symptomatic irreversible pulpitis, and the ways in which dentists managed endodontic emergencies during the COVID-19 lockdown. A total of 1,058 dentists responded to the questionnaire; 344 (32.6%) of the participants were endodontists. Slightly less than half of the participants (n = 485, 45.8%) worked during the lockdown, but only 303 participants (28.6%) treated endodontic cases/emergencies. The responses showed agreement between endodontists and GDPs regarding the diagnosis of symptomatic irreversible pulpitis (SIP), symptomatic apical periodontitis (SAP), reversible pulpitis, and asymptomatic irreversible pulpitis (AIP). SIP and SAP were considered an emergency, whereas reversible pulpitis and AIP were not considered an emergency (p > 0.05). Non-aerosol-generating procedures and treatment approaches differed between the groups (p < 0.05). One-third of the participants did not use rubber dam (p > 0.05). Ibuprofen and amoxicillin-clavulanic acid were the most frequently prescribed drugs for pain associated with SIP. In conclusion, the most relevant findings in our survey were the differences between endodontists and GDPs in diagnosis, precheck triage, deep caries excavation procedures, and endodontic emergency pain relief strategies.

Aim: The study aimed to assess oral health knowledge, dental behaviors, and use of dental services in individuals with vision impairment in Jordan and identify barriers that affect their access to dental care in comparison with individuals without vision impairment. Materials and Methods: A case-control study was carried out among 399 parents/caregivers of individuals with vision impairment and individuals without vision impairment, which involved the completion of a self-designed questionnaire. A closed-ended, validated self-designed questionnaire was distributed. The questionnaire included questions addressing participants’ oral health knowledge, oral health behaviour, dental service use and barriers to accessing dental care. Data were analyzed using SPSS^® software Version 22 with a 0.05 level of significance. A Chi-square test and contingency-table analysis were performed on the data. Results: Individuals with vision impairment in Jordan were significantly less knowledgeable about different oral health aspects than sighted counterparts. In addition, individuals with vision impairment used toothbrush, dental floss, and mouth rinse less frequently. They also visited dentists less regularly and mostly when only feeling pain. Limited access to dental services was observed among individuals with vision impairment compared to sighted individuals. Barriers, including embarrassment (22%), lack of knowledge of how to treat people with disabilities among dentists (12.5%), and inadequate facilities (13.7%), were significantly (P<0.05) more likely to be reported by visually impaired participants than the controls. Conclusion: Visually impaired individuals and their families should be given appropriate education about oral health care by oral health professionals to reduce the risk of having dental problems and oral disease and enhance their quality of life. Furthermore, recognizing the challenges in accessing dental care for this population could help oral health professionals to minimize these difficulties.

Introduction: Biodentine is a well-known endodontic material that is applied in various endodontic therapies. Enterococcus faecalis (E. faecalis) is associated with endodontic failure and persistent periapical infection. The purpose of this systematic review was to summarize the available evidence regarding the antibacterial activity of Biodentine against E. faecalis and to compare it to other commercial endodontic materials.Methods: An electronic search of literature was conducted in PubMed, Scopus, Web of Science, and Google Scholar in addition to a manual search in specialized journals up to May 2024. The eligibility criteria, data extraction, and evaluation of risk of bias were assessed by two independent authors. The risk of bias was evaluated in accordance with Modified CONSORT checklist items for pre-clinical in vitro studies on dental materials.Results: Out of 343 studies, thirty-seven fulfilled the inclusion criteria and were included in this review. Thirty studies reported a good antibacterial efficacy of Biodentine against E. faecalis. Biodentine was superior to or, at least, as efficacious as MTA, MTA Angelus, GIC, RMGIC, DiaRoot BioAggregate, NeoPutty, iRoot FS, MTA Repair HP, MTA Biorep, Well-Root PT, Activa, NeoMTA 2, Calcimol LC, TotalFill, and IRM. The findings were supported by studies with medium to high risk of bias (low quality).Conclusions: Considering the limitations of this systematic review, there is accumulating evidence on the antibacterial activity of Biodentine against E. faecalis in context of endodontics. However, randomized clinical trials with well-designed and robust methodologies are required in order to provide information about its clinical behaviour.