Automatic retinal vessel segmentation is important for the diagnosis and prevention of ophthalmic diseases. The existing deep learning retinal vessel segmentation models always treat each pixel equally. However, the multi-scale vessel structure is a vital factor affecting the segmentation results, especially in thin vessels. To address this crucial gap, we propose a novel Fully Attention-based network (FANet) based on attention mechanisms to adaptively learn rich feature representation and aggregate the multi-scale information. Specifically, the framework consists of the image pre-processing procedure and the semantic segmentation networks. Green channel extraction (GE) and contrast limited adaptive histogram equalization (CLAHE) are employed as pre-processing to enhance the texture and contrast of retinal blood images. Besides, the network combines two types of attention modules with the U-Net. We propose a lightweight dual-direction attention block to model global dependencies and reduce intra-class inconsistencies, in which the weights of feature maps are updated based on the semantic correlation between pixels. The dual-direction attention block utilizes horizontal and vertical pooling operations to produce the attention map. In this way, the network aggregates global contextual information from semantic-closer regions or a series of pixels belonging to the same object category. Meanwhile, we adopt the selective kernel(SK) unit to replace the standard convolution for obtaining multi-scale features of different receptive field sizes generated by soft attention. Furthermore, we demonstrate that the proposed model can effectively identify irregular, noisy, and multi-scale retinal vessels. The abundant experiments on DRIVE, STARE, and CHASE_DB1 datasets show that our method achieves state-of-the-art performance.

The prevention, evaluation, and treatment of hypertension have attracted increasing attention in recent years. As photoplethysmography (PPG) technology has been widely applied to wearable sensors, the noninvasive estimation of blood pressure (BP) using the PPG method has received considerable interest. In this paper, a method for estimating systolic and diastolic BP based only on a PPG signal is developed. The multitaper method (MTM) is used for feature extraction, and an artificial neural network (ANN) is used for estimation. Compared with previous approaches, the proposed method obtains better accuracy; the mean absolute error is 4.02 ± 2.79 mmHg for systolic BP and 2.27 ± 1.82 mmHg for diastolic BP.

Congestive heart failure (CHF) refers to the inadequate blood filling function of the ventricular pump and it may cause an insufficient heart discharge volume that fails to meet the needs of body metabolism. Heart rate variability (HRV) based on the RR interval is a proven effective predictor of CHF. Short-term HRV has been used widely in many healthcare applications to monitor patients’ health, especially in combination with mobile phones and smart watches. Inspired by the inception module from GoogLeNet, we combined long short-term memory (LSTM) and an Inception module for CHF detection. Five open-source databases were used for training and testing, and three RR segment length types (N = 500, 1000 and 2000) were used for the comparison with other studies. With blindfold validation, the proposed method achieved 99.22%, 98.85% and 98.92% accuracy using the Beth Israel Deaconess Medical Center (BIDMC) CHF, normal sinus rhythm (NSR) and the Fantasia database (FD) databases and 82.51%, 86.68% and 87.55% accuracy using the NSR-RR and CHF-RR databases, with N = 500, 1000 and 2000 length RR interval segments, respectively. Our end-to-end system can help clinicians to detect CHF using short-term assessment of the heartbeat. It can be installed in healthcare applications to monitor the status of human heart.

Uveal melanoma is the most common primary intraocular malignancy in adults, with nearly half of all patients eventually developing metastases, which are invariably fatal. Manual assessment of the level of expression of the tumor suppressor BRCA1-associated protein 1 (BAP1) in tumor cell nuclei can identify patients with a high risk of developing metastases, but may suffer from poor reproducibility. In this study, we verified whether artificial intelligence could predict manual assessments of BAP1 expression in 47 enucleated eyes with uveal melanoma, collected from one European and one American referral center. Digitally scanned pathology slides were divided into 8176 patches, each with a size of 256 × 256 pixels. These were in turn divided into a training cohort of 6800 patches and a validation cohort of 1376 patches. A densely-connected classification network based on deep learning was then applied to each patch. This achieved a sensitivity of 97.1%, a specificity of 98.1%, an overall diagnostic accuracy of 97.1%, and an F1-score of 97.8% for the prediction of BAP1 expression in individual high resolution patches, and slightly less with lower resolution. The area under the receiver operating characteristic (ROC) curves of the deep learning model achieved an average of 0.99. On a full tumor level, our network classified all 47 tumors identically with an ophthalmic pathologist. We conclude that this deep learning model provides an accurate and reproducible method for the prediction of BAP1 expression in uveal melanoma.

The grain drying is difficult to control because of its characteristics of long delay, strong nonlinearity, and uncertainty parameters. The aim of the paper is to design a suitable controller for a newly designed grain dryer. First, a nonlinear math model of the wheat mixed flow drying was established and analyzed based on the fundamental laws of simultaneous heat and mass transfer. The simulations for the batch circulating drying process and the continuous grain drying process have been made and the simulation results show that it fits well with the actual drying process. Second, an internal model proportional integral derivative (PID) controller (IMPC) based on the support vector machine (SVM) algorithm and the genetic algorithm (GA-SVM-IMPC) was proposed from the view of the energy loss and the dried grain quality. The structure of the GA-SVM-IMPC controller consists of a SVM prediction model, a SVM inverse model controller, a PID controller and a genetic optimization algorithm. Finally, the effectiveness of this controller was demonstrated by computer simulations, and the comparative study with the other controllers further confirmed the superiority of the proposed dryer controller.

Reconstruction of a 12-lead electrocardiogram (ECG) from a serial 3-lead ECG has been researched in the past to satisfy the need for more wearing comfort and ambulatory situations. The accuracy and...