Titanium-based dental implants have evolved significantly, with the development of binary alloys like Ti-15Zr (Roxolid™) representing a pivotal advancement in mechanical performance. Current research focuses on biomimetic surface engineering to further accelerate osseointegration and optimize bone regeneration, particularly in clinically compromised sites. This review constitutes a narrative synthesis of how these strategies replicate the bone extracellular matrix (ECM) through a holistic framework of architectural, mechanical, and biochemical integration. A structured literature search across PubMed, Scopus, and Web of Science (2010–2026) identified relevant studies focusing on the synergy between Ti-15Zr substrates and surface modifications. Evidence confirms that the high fatigue strength of Roxolid™ alloys provides an ideal foundation for advanced, hierarchical surface engineering without compromising structural integrity. This strategy utilizes macro-topography for primary stability, nano-topography for protein adsorption, and bio-functionalization (e.g., RGD peptides, osteogenic ions) to direct mesenchymal stem cell (MSC) differentiation. This synergy accelerates the transition from passive to active osseointegration, effectively bridging the "biological gap" during early healing. Biomimetic engineering transforms implants into instructive biological platforms, improving outcomes for patients with compromised bone quality and facilitating predictable immediate loading protocols.

Titanium-based dental implants have evolved significantly, with the development of binary alloys like Ti-15Zr (Roxolid™) representing a pivotal advancement in mechanical performance. Current research focuses on biomimetic surface engineering to further accelerate osseointegration and optimize bone regeneration, particularly in clinically compromised sites. This review constitutes a narrative synthesis of how these strategies replicate the bone extracellular matrix (ECM) through a holistic framework of architectural, mechanical, and biochemical integration. A structured literature search across PubMed, Scopus, and Web of Science (2010–2026) identified relevant studies focusing on the synergy between Ti-15Zr substrates and surface modifications. Evidence confirms that the high fatigue strength of Roxolid™ alloys provides an ideal foundation for advanced, hierarchical surface engineering without compromising structural integrity. This strategy utilizes macro-topography for primary stability, nano-topography for protein adsorption, and bio-functionalization (e.g., RGD peptides and osteogenic ions) to direct mesenchymal stem cell (MSC) differentiation. This synergy accelerates the transition from passive to active osseointegration, effectively bridging the “biological gap” during early healing. Biomimetic engineering transforms implants into instructive biological platforms, improving outcomes for patients with compromised bone quality and facilitating predictable immediate loading protocols.

The aim of the study was to compare the sealing of two different core techniques (SoftCore and Guttafusion) associated to a bioceramic sealer (NeoSealer Flo). Eight tooth models (upper first molar) with simulated canals were used in this study. The models were divided into two groups: Group 1 (samples 1 to 4): Root canals were obturated with GuttaFusion. Group 2 (samples 5 to 8): Root canals were obturated with SoftCore. Both groups were filled with NeoSealer Flo sealer. Only the P and DV canals were obturated for each model. The models were sectioned at 1mm and 3mm from the apex. The total area of each canal segment was measured, and the areas were converted into the percentage of “Gutta-percha-filled areas”, ” Cement-filled areas”, “Void areas”. At 1mm from the apex GuttaFusion (GF) produced a higher PGFA and a lower PSFA value compared to SoftCore (SC). Additionally, SC produces a higher PGVA compared to GF. The values of PGFA, PSFA, and PVA are also comparable in the sections taken at 3mm from the apex. Comparing the two different techinques, a higher PGFA in GuttaFusion (GF) and a higher PSFA in SoftCore (SC) were found, while the VA was greater but comparable in both techniques, with a slight increase in percentage in the SC technique. At 3 mm, a higher PGFA was found compared to the PGFA at 1 mm.

The aim of this preliminary study was to compare two core-carrier obturation techniques—GuttaFusion (GF) and SoftCore (SC)—used in combination with a bioceramic sealer (NeoSealer Flo), and to evaluate their ability to fill simulated root canals. Eight standardized resin models of maxillary first molars were used, and only the P and DV canals of each model were obturated. Cross-sections were obtained at 1 mm and 3 mm from the apex, and the percentage areas occupied by gutta-percha (PGFA), sealer (PSFA), and voids (VA) were measured. This study provides novel comparative data on the performance of these two carrier-based techniques when used with a bioceramic sealer. GF showed higher PGFA and lower PSFA compared with SC at 1 mm from the apex, while SC presented slightly higher VA. At 3 mm, PGFA increased for both techniques. Descriptive statistics (means and percentage values) were calculated; no inferential statistical analysis was performed due to the preliminary nature of the study and the limited sample.