Prof. Young Chul Kim

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Academic Career Length

20Years (2007-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2010 in The Korean Journal of Physiology & Pharmacology

Journal Article

Regional Distribution of Interstitial Cells of Cajal (ICC) in Human Stomach

Hyo-Yung Yun

Rohyun Sung

Young Chul Kim

Woong Choi

Hun Sik Kim

Sang Jin Lee

Yun HY, et al. Korean J Physiol Pharmacol. 2010 Oct;14(5):317-324. http://dx.doi.org/10.4196/kjpp.2010.14.5.317

7 February 2007 in Pflügers Archiv - European Journal of Physiology

Journal Article

Regulation of membrane excitability by intracellular pH (pHi) changers through Ca2+-activated K+ current (BK channel) in single smooth muscle cells from rabbit basilar artery

Jong Kook Park

Young Chul Kim

Jae Hoon Sim

Mi Young Choi

Woong Choi

Sang Jin Lee

1 January 2016 in Journal of Veterinary Medical Science

Journal Article

Regulation of myometrial contraction by ATP-sensitive potassium (KATP) channel via activation of SUR2B and Kir 6.2 in mouse

Seung Hwa Hong

Kyu-Sang Kyeong

Chan Hyung Kim

Young Chul Kim

Woong Choi

Sang Jin Lee

ATP-sensitive potassium (KATP) channels are well characterized in cardiac, pancreatic and many other muscle cells. In the present study, functional expression of the KATP channel was examined in non-pregnant murine longitudinal myometrium. Isometric contraction measurements and Western blot were used. KATP channel openers (KCOs), such as pinacidil, cromakalim, diazoxide and nicorandil, inhibited spontaneous myometrial contractions in a reversible and glibenclamide-sensitive manner. KCOs inhibited oxytocin (OXT)- and prostaglandin F2α (PGF2α)-induced phasic contractions in a glibenclamide-sensitive manner. SUR2B and Kir6.2 were detected by Western blot, whereas SUR1, SUR2A and Kir6.1 were not. These results show that pinacidl, cromakalim, diazoxide and nicorandil-sensitive KATP channels exist in murine myometrium, which are composed of SUR2B and Kir6.2. Based on the modulatory effects of the KATP channel on spontaneous contraction, OXT- and PGF2α-induced contractions, KATP channels seem to play an essential role in murine myometrial motility via activation of SUR2B and Kir6.2.