Background: Endothelial dysfunction plays a critical role in ischemic stroke. The Endothelial Activation and Stress Index (EASIX), calculated from creatinine, lactate dehydrogenase (LDH), and platelet levels, reflects endothelial injury. This study aimed to investigate the relationship between EASIX and 90-day mortality in patients with posterior circulation ischemic stroke (PCIS) treated with mechanical thrombectomy. Methods: Fifty-eight patients with acute ischemic stroke who underwent mechanical thrombectomy (MT) or MT combined with intravenous thrombolysis (intravenous tissue plasminogen activator (tPA)) for posterior circulation ischemic stroke (PCIS) were included. EASIX was calculated using 24 h laboratory values of creatinine, LDH, and platelets. Its association with 90-day mortality, length of hospital stay, intubation, and parenchymal hemorrhage was analyzed. Results: In patients receiving reperfusion therapy, the Endothelial Activation and Stress Index (EASIX) showed modest ability to predict 90-day mortality (AUC = 0.583, 95% CI 0.428–0.739, p = 0.295). Higher EASIX values were linked to a 6.58-fold increase in mortality risk. Patients with elevated EASIX were generally older, had more frequent hyperlipidemia, had higher 24 h National Institutes of Health Stroke Scale (NIHSS) scores, had greater need for intubation, and had higher in-hospital mortality. Conclusions: EASIX is a simple, inexpensive, and non-invasive marker that may reflect endothelial dysfunction and help predict mortality in PCIS patients undergoing reperfusion therapy. Higher EASIX values are associated with poorer prognosis. Early identification of high-risk patients may support secondary prevention strategies.

The postpartum period is a well-defined risk factor for cerebral venous sinus thrombosis (CVST). However, it is unclear which patients are at risk for CVST in the postpartum period. Thus, determining some CVST risk factors in postpartum patients may be useful for preventing the disorder in this population. Previous studies have shown that preeclampsia (PE) is a risk factor for pulmonary thromboembolism and deep vein thrombosis, but whether it is related to postpartum CVST has not yet been evaluated. This study aimed to determine if this relationship exists. This study was a case–control study of retrospectively screened patients diagnosed with CVST between 2018 and 2023 at the Uludağ University Faculty of Medicine Department of Neurology, the Eskişehir Osmangazi University Faculty of Medicine and the Bursa City Hospital Health Sciences University Department of Neurology. All of the women who delivered between 2018 and 2023 at the Uludağ University Faculty of Medicine Department of Obstetrics and Gynaecology were included in the control group. In total, 57 out of 322 cases and 4299 out of 4452 controls were included in this study. A nonsignificant relationship was found between CVST and spinal anesthesia, but a significant relationship was found between PE and stillbirth. Women with PE who had recently delivered were found to be at increased risk of developing CVST. The primary limitation of this study is that it was retrospective, and the control group was hospital-based. We recommend that these findings be confirmed by multicenter prospective international studies.

Aim: Loss of balance can be seen in idiopathic Parkinson's disease (IPD) There are only a few studies in the literature in which brainstem involvement in IPD has been researched with neurophysiological tests such as vestibular evoked myogenic potential (VEMP). In this study, it was investigated whether there is a difference in the results of VEMP testing in early or late stage of IPD. Material and method: The IPD cases were classified as early stage and late stage according to the Hoehn-Yahr scale. The presence of a positive wave with a latency of P13 and a negative wave with a latency of N23 was investigated as the first reflex response The latencies of these potentials and the absolute amplitude of the P13-N23 component were measured. The VEMP results of the patients with early and late stage IPD were compared with those of the control group. Results: The right P13 latency mean value in the late stage patient group was significantly prolonged than in the early stage patient group and the control group. The right P13-N23 amplitude mean value of the late and early stage patient groups was significantly smaller than that of the control group (p < 0.002 and p < 0.001, respectively). Among the patients with IPD, the P13 latency was statistically increased in those with a fall history than in those without a fall history. In conclusion, this study indicates that the VEMP pathway is affected over time especially in patients with late stage Parkinson’s disease.

Objective: Obesity may cause cognitive dysfunctions such as attention, processing speed, memory, and executive functioning. However, little is known about how obesity can affect cognitive functions in obese individuals. Sensory gating shows the early pre-attention period in information processing and is accepted to be the result of the integration of multi-step procedures that can be tested with the double click P50 paradigm. The aim of this study is to investigate changes in cognitive functions with sensory gating in obese individuals. Methods : A total of 31 obese individuals and age- and sex-matched healthy 24 control subjects were included in the study. The latencies and amplitude P50 waves were measured in the healthy controls and obese individuals. Also the P50 sensory gating was calculated. Results : We found a significant difference between the obese group and controls regarding the amplitude of the first P50 wave (p<0.048). The obese group showed reduced P50 sensory gating as compared to controls (p<0.004). Conclusion: The findings suggest that obese individuals have a sensory gating abnormality seems to be a result of cholinergic dysfunction. This results may help explain congnitive impairment in obese individuals.

Introduction: The aging population is one of the main reasons for the increase in stroke cases.The aim of this study was to evaluate the predictors of 3-month outcomes in patients aged ≥65 years who underwent mechanical thrombectomy for acute ischemic stroke and compare patients aged 65–79 years with those aged ≥80 years in terms of demographic characteristics, workflow, functional outcomes, and complication rates. Materials and Method: This retrospective cohort study included 169 consecutive patients aged ≥65 years who underwent mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion between April 2020 and May 2023. Results: Recanalization was successful for 148 (87.57%) patients.According to multivariable logistic regression analysis results, low (≤9) Alberta Stroke Program Early Computed Tomography score (odds ratio: 4.217, 95% confidence interval: 1.209–14.715, and p=0.024), high National Institutes of Health Stroke Scale score at 24th hour (odds ratio: 1.192, 95% confidence interval: 1.087–1.306, and p<0.001), high Acute Physiology and Chronic Health Evaluation score (odds ratio: 1.127, 95% confidence interval: 1.016–1.250, and p=0.023), and intubation need (odds ratio: 15.055, 95% confidence interval: 2.087–108.612, and p=0.007) were independent predictors of poor outcome. Conclusion: The lack of significant differences in workflow, functional outcomes, and complications among patients ˃80 years of age indicates that MT is effective in this age group. Considering the aging population, identifying the predictors of 3-month outcomes after mechanical thrombectomy will help predict outcomes, better identify elderly patients who may benefit from the procedure, and guide treatment decisions. Keywords: Aged; Ischemic Stroke; Endovascular Procedures; Thrombectomy.