1,5-disubstituted tetrazoles (1,5-Ds-T) are heterocyclic bioisosteres of the cis-amide bond, commonly found in bioactive compounds, pharmaceuticals, and functional materials. Chromones are privileged scaffolds widely present in natural products that are well known for their diverse biological activities, including anticancer, antimicrobial, antidiabetic, anti-inflammatory, and antioxidant properties. Isocyanide-based multicomponent reactions, such as the Ugi-Azide (UA-4CR), provide a versatile strategy for synthesizing 1,5-Ds-T, which can be incorporated into other privileged heterocyclic or commercially available drugs. Herein, we describe a sonochemical one-pot synthesis of 1,5-Ds-T connected to chromone under mild conditions, highlighting their potential relevance in medicinal chemistry.

Imidazo[1,2-a]pyridines (IMPs) are valuable heterocycles, present in bioactive compounds and drugs. Analogs that incorporate azide moieties are useful intermediates in organic synthesis and can be used as synthetic platforms to access more complex products. Isocyanide-based multicomponent reactions such as Groebke–Blackburn–Bienaymé (GBB-3CR) are versatile tools to synthesized IMPs, in which orthogonal reagents are included into components to increase its synthetic potential. Herein we developed a one-pot process to access IMPs functionalized with azides under mild conditions, which are synthetic platforms for further post-transformations.