Temperature Swing Absorption (TSA) is the primary candidate for the Isotope Rebalancing and Protium Removal (IRPR) system within the envisioned EU-DEMO fusion reactor fuel cycle. TSA separates a mixed hydrogen isotope stream into two product streams using a semi-continuous process. One stream, enriched in heavy isotopes, is used to re-establish the required deuterium-to-tritium fuel ratio. The second, enriched in protium, is stripped off from the fuel cycle to counteract the protium build-up. Separation is achieved by cycling an isotope mixture between two columns filled with metallic absorption materials that have opposite isotope effects of metal hydride formation. The selection of these materials, the operation parameters and the column geometry allow for adjusting the resulting enrichments. To identify suitable operation parameters, a TSA process model is developed which depicts the process dynamics and interactions between the columns. A modified process operation mode is introduced, which enables higher system throughputs and non-cryogenic operation, i.e., operational temperatures between 0 to 130 °C, while reducing the tritium inventory due to shorter cycling times by reduced amplitudes of the temperature swings. Finally, simulations of a TSA system at relevant scale confirm the suitability of TSA technology for the separation task of the EU-DEMO IRPR system.