The dendritic cell (DC)‐T cell axis is a bridge that connects innate and adaptive immunities. The initial immune response against tumors is mainly induced by mature antigen‐presenting DCs. Enhancing the crosstalk between DCs and T cells may be an effective approach to improve the immune response to non‐small cell lung cancer (NSCLC). In this article, a review was made of the interaction between DCs and T cells in the treatment of NSCLC and how this interaction affects the treatment outcome.

Cardio-cerebrovascular disease has seen a rapid rise in recent years, with Heart Failure (HF) -- a terminal stage of various cardiovascular diseases -- also on the rise. HF has a complex pathogenesis involving multiple factors, such as inflammation, fibrosis, and oxidative stress. Due to its unique reverse shear mechanism, HF exhibits distinct expression patterns across different diseases. CircRNA has been linked to conditions like cancer, diabetes, and osteoarthritis. This article briefly introduces the mechanisms of circRNA biogenesis and its associated biological functions, focusing on CircSLC8A1-1, CircRNA_000203, and others at the early stage of HF, CircRNA PAN3, CircRNA (ACR), and others during the progression of HF, and CircHIPK3, CircNfix, and others at the end stage of HF. These circRNAs play a participatory role in the exact mechanism. As a research method, circRNA can be utilized to study the pathogenesis of heart failure and serve as a target for drug discovery and development. Therefore, circRNA's ability to mark the disease at different stages has significant guiding implications for HF monitoring, treatment, and prognosis.

The three major organ systems of heart, kidney and bone are highly correlated in physiology and pathology. They form the “heart-kidney-bone axis” together. The typical clinical manifestations of this axis include the deterioration of heart and kidney function, reflected by cardiorenal syndrome, renal bone disease, and cardiovascular calcification contained in chronic kidney disease-mineral bone disorder (CKD-MBD). However, the core molecular mechanism that regulates this axis has not been fully understood. O-linked N-acetylglucosamine (O-GlcNAc) glycosylation modification is a dynamic, reversible and highly conserved protein post-translational modification (PTM). It integrates body nutrition and stress signals via the hexosamine biosynthesis pathway (HBP), extensively participates in fine cellular function regulation, and plays an essential role in the progression of heart, kidney and bone diseases. This review systematically summarizes the role and multidimensional regulatory network characteristics of O-GlcNAcylation in heart, kidney and skeletal systems. It focuses on exploring its cross-organ regulatory mechanism in the “heart-kidney-bone axis”, and aims to provide new ideas for the mechanism analysis and targeted therapy of comorbidities.

The DC-T cell axis is a bridge connecting innate immunity and adaptive immunity. The initial immune response against tumors is mainly induced by mature antigen-presenting dendritic cells (DC). Enhancing the crosstalk between DC and T cells could improve the immune response to non-small cell lung cancer. This article reviews the interaction between DC-T cells in the treatment of non-small cell lung cancer and how this interaction impacts the treatment outcome.