Filip Willemse

Mr. Filip Willemse

orcid

Research Focus & Metrics

Academic Career Length

2Years (2025-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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23 December 2025 in Pharmaceutics
Verified
Journal Article
Open access
PDF file
BABehrad Aminahmadi
Behrad Aminahmadi
EVElise Vaes
Elise Vaes
FWFilip Willemse
Filip Willemse
DBDomenica Braile
Domenica Braile
LGLuz Naranjo Gomez
Luz Naranjo Gomez
Ashish KumarAshish Kumar
Ashish Kumar
Tablet film coating is governed by three interrelated phenomena, namely, tablet mixing, coating-liquid spraying, and liquid evaporation, which dominate the critical quality attributes (CQAs) of the final product. This review examines how differences in coater design, key process parameters, and quality control strategies impact these phenomena and ultimately affect inter-tablet and intra-tablet coating variability. Two complementary approaches for understanding and optimizing the process are evaluated. The experimental approach, involving Design of Experiments (DoE), retrospective data analysis, and advanced Process Analytical Technology (PAT), provides empirical insight into factor–response relationships and enables real-time quality assurance. Simultaneously, model-based approaches, including thermodynamic, spray-dynamics, and particle-dynamics modelling, offer mechanistic understanding of heat and mass transfer, droplet deposition patterns, and tablet motion. Although these sub-models have advanced considerably over the years, a predictive model that treats the coating process in its entirety is still missing. Overall, this review underscores that future advancements will require integrating experimental and model-based methodologies to achieve robust, quality-driven, and predictive control of tablet film coating processes.

29 July 2025 in European Journal of Pharmaceutics and Biopharmaceutics
Verified
Journal Article
Closed access
SDSien Dedroog
Sien Dedroog
JOJiabi Ouyang
Jiabi Ouyang
EVElise Vaes
Elise Vaes
FWFilip Willemse
Filip Willemse
SASune Klint Andersen
Sune Klint Andersen
Guy Van den MooterGuy Van den Mooter
Guy Van den Mooter