As a consequence of increasing reports of an unusual and novel presentation of a multisystem inflammatory disease in the UK, the Royal College of Paediatrics and Child Health published a case definition on May 1, 2020, of pediatric inflammatory multisystem syndrome temporally associated with coronavirus disease 2019 (COVID-19) (PIMS-TS).
1 They defined PIMS-TS as persistent fever, inflammation, and evidence of single or multiorgan dysfunction, with exclusion of any other microbial cause and with positive or negative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction test results. In the US, this condition has been defined by the Centers for Disease Control and Prevention as multisystem inflammatory syndrome in children, with a more specific case definition.
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