This paper establishes an integrated framework combining self-induced vibration measurements with deep learning for vibration-based remaining useful life (RUL) prediction of mechanical frame structures in mobile robots. The main innovations comprise (1) a self-induced vibration excitation system that utilizes the robot’s drive wheels to generate controlled mechanical oscillations, using a five-sensor micro-electro-mechanical system (MEMS) accelerometer array to capture non-uniform vibration mode shapes across the robot’s structure, and (2) a processing pipeline for RUL prediction using accelerometer data and early feature fusion in two machine-learning models (long short-term memory (LSTM) and a convolutional neural network (CNN)). Our research methodology includes (i) modal analysis to identify the robot’s natural frequencies, (ii) verification platform evaluation, comparing low-cost MEMS accelerometers against a reference integrated electronic piezoelectric (IEPE) accelerometer, demonstrating industrial-grade measurement quality (coherence > 98%, uncertainty 4.79–7.21%), and (iii) data-driven validation using real data from the mechanical frame, showing that the LSTM model outperforms the CNN with a 2.61× root-mean-square error (RMSE) improvement (R² = 0.99). Our solution demonstrates that early feature fusion provides sufficient information to model degradation and detect faults early at a lower cost, offering a feasible alternative to classical maintenance procedures through combined hardware validation and lightweight software suitable for Industrial Internet-of-Things (IIoT) deployment.