Korean Circulation Journal 대한심장학회지 순환기 Kim HL, et al. Korean Circ J. 2022 Feb;52(2):93-109. https://doi.org/10.4070/kcj.2021.0328

Yang DY, et al. World J Mens Health. 2025 Jan;43(1):188-196. https://doi.org/10.5534/wjmh.230327

The American College of Cardiology and American Heart Association (ACC/AHA) guidelines identified four statin benefit groups on the basis of atherosclerotic cardiovascular disease risk reduction and proposed statin therapy by evidence-based intensity. Although these guidelines used randomized controlled trials with hard outcomes as exclusive evidence for its recommendations, a limited number of studies conducted in Asian countries makes its application of treatment strategy, intensity, and statin doses uncertain in these population. This prospective, multicenter study aimed to evaluate the efficacy of rosuvastatin 10 mg in the four statin benefit groups requiring high- or moderate-intensity statin therapy according to the ACC/AHA guidelines in the Korean population. The primary endpoint was percentage reduction in low-density lipoprotein (LDL) cholesterol. Secondary endpoints were percentage reduction in other lipids and achievement of ≥50% reduction in LDL cholesterol. Rosuvastatin 10 mg lowered LDL cholesterol by 61.4 mg/dL, a 44.9% decrease from baseline after eight weeks. Reduction of LDL cholesterol ≥50% was achieved in 46.3% of patients. Rosuvastatin 10 mg was generally well tolerated. In the Korean population, rosuvastatin 10 mg was favorable and tolerant in lowering LDL cholesterol in the four statin benefit groups requiring high- or moderate-intensity statin therapy according to the ACC/AHA guidelines.

Background: Although brachial–ankle pulse wave velocity (baPWV) has been used to predict cardiovascular events, studies comparing it with brachial pulse pressure (brPP) for predictive value have been lacking. We investigated how brPP and baPWV differ in their ability to predict future cardiovascular events. Methods: We retrospectively reviewed the clinical data of 11,703 consecutive patients where brPP and baPWV measurements had been made. The primary endpoint was differences in the incidence of major adverse cardiovascular and cerebrovascular events (MACCE). Results: Participants had a median age of 61 years, and men accounted for 57.7% of the cohort. During a median follow-up duration of 3.64 years, 347 (3.0%) MACCE occurred. Using established reference values of baPWV > 1800 cm/s and brPP > 60 mmHg, we, respectively, stratified patients by these values. Kaplan–Meier survival curve analysis revealed that both high baPWV and brPP groups displayed elevated MACCE incidence, all-cause mortality, and cardiovascular mortality. After controlling for potential confounders, multivariate Cox regression analysis showed that individuals with elevated baPWV had higher rates of MACCE, overall mortality, and cardiovascular death, whereas brPP was not significantly associated with these outcomes. Subgroup analysis showed a consistent difference in MACCE incidence across all subgroups when stratified by baPWV; however, the significance disappeared in several subgroups when stratified by brPP. Conclusions: baPWV exhibited a stronger association with MACCE incidence than brPP. Thus, baPWV may be a more effective factor than brPP for cardiovascular risk stratification.

BACKGROUND: The efficacy and safety of each third-generation drug-eluting stent with ultrathin struts and advanced polymer technology remain unclear. We investigated the clinical outcomes of percutaneous coronary intervention using the Coroflex ISAR polymer-free sirolimus-eluting stent (SES) or Orsiro biodegradable polymer SES. METHODS: The HOST-IDEA trial (Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis–Coronary Intervention With Next-Generation Drug-Eluting Stent Platforms and Abbreviated Dual Antiplatelet Therapy), initially designed with a 2×2 factorial approach, sought to randomize patients undergoing percutaneous coronary intervention based on dual antiplatelet therapy duration (3 versus 12 months) and stent type (Coroflex ISAR versus Orsiro). Despite randomizing 2013 patients for dual antiplatelet therapy duration, the stent arm transitioned to a registry format during the trial. Among these, 328 individuals (16.3%) were randomized for Coroflex ISAR or Orsiro SES, while 1685 (83.7%) underwent percutaneous coronary intervention without stent-type randomization. In this study, the Coroflex ISAR (n=559) and Orsiro groups (n=1449) were matched using a propensity score. The prespecified primary end point was target lesion failure, a composite of cardiac death, target vessel myocardial infarction, and clinically driven target lesion revascularization at 12 months. RESULTS: The baseline patient and procedural characteristics were well balanced between the Coroflex ISAR and Orsiro groups after propensity score matching (n=559, each group). The Coroflex ISAR group was significantly associated with a higher rate of target lesion failure, mainly driven by clinically driven target lesion revascularization, compared with the Orsiro group (3.4% versus 1.1%; hazard ratio, 3.21 [95% CI, 1.28–8.05]; P =0.01). A higher risk of target lesion failure in the Coroflex ISAR group was consistently observed across various subgroups. The rates of any bleeding (hazard ratio, 0.85 [95% CI, 0.51–1.40]; P =0.52) and major bleeding (hazard ratio, 1.58 [95% CI, 0.61–4.08]; P =0.34) were comparable between the 2 groups. CONCLUSIONS: In this propensity score-matched analysis of the stent arm registry from the HOST-IDEA trial, the Orsiro SES was associated with significantly better outcomes in terms of 1-year target lesion failure, mainly driven by clinically driven target lesion revascularization, than the Coroflex ISAR SES. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02601157.

The aim of the study was to determine the influence of different exercise types on health-related quality of life (QOL) in men with depressive disorder (DD) in South (S) Korea. The data of 385 men aged 19 with DD were collected in S. Korea. The Euro Quality of Life 5 Dimensions (EQ-5D) index and Korea National Health and Nutrition Examination Survey (KNHANES) questionnaires were used to establish the purpose of this study. Furthermore, the complex sampling model was applied to investigate the influence of different exercise types on health-related QOL in participants. When reviewing the outcomes, the strength exercise and walking had significant influences on health-related QOL in men with DD in S. Korea. However, the flexibility exercise did not have a significant influence on them. Based on the results, strength exercise and walking were effective exercise types to increase levels of health-related QOL in men with DD in S. Korea.