In this work, different materials based on TiO₂ coupled with either AgBr or Ag₃PO₄ were synthesized. The Ag₃PO₄(50%)/TiO₂ powder photocatalyst prepared by deposition–precipitation method showed higher antimicrobial activity than the bare TiO₂ and also than the same coupled powder obtained by sol–gel method. This material achieved 100% E. coli, coliforms, and other enterobacteria elimination. The high bactericidal efficiency of this material could be attributed to the improved properties obtained by coupling Ag₃PO₄ and TiO₂, such as high absorption in the visible region, low band-gap value, and high surface hydroxylation. The sol–gel method was chosen for the production of photocatalytic coatings on borosilicate glass tubes based on TiO₂ and Ag₃PO₄/TiO₂ materials due to the ease of its preparation procedure and its suitability for dip coating. In this series, the most effective elimination of E. coli, coliforms, and other enterobacteria was achieved with the glass tubes coated with the laboratory–prepared TiO₂ sol. Interestingly, this material presented superior antimicrobial performance as coating (100% of E. coli elimination) compared to its powder form. The titania coating also showed the best efficiency in the degradation of methylene blue (i.e., 95.2%), though this material lost 30% of its photoactivity after four reaction cycles.