The magmatic activity is crucial for identify the tectonic framework of ancient ocean. In this study, a systematically work including field survey, zircon LA-ICP-MS U-Pb dating, and whole-rock geochemical analysis is carried on to investigated the intrusive magmatic rocks of quartz diorite and granodiorite within the Meso-Tethyan Shiquanhe Ophiolitic Mélange (SQM), Tibet. Zircon U-Pb dating yields the weighted mean ages of 174.7±1.4 Ma (quartz diorite) and 178.9±1.2 Ma (granodiorite) respectively, indicating the Early Jurassic formation age. The quartz diorite is metaluminous (A/NKC = 0.77-0.95), while the granodiorite is weakly peraluminous (A/NKC = 0.95-1.21), and both of them exhibit tholeiitic–calc-alkaline geochemical characteristics and classified as I-type granites. The right-dipping rare earth element (REE) patterns, enrichment in large ion lithophile elements (LILEs: Rb, Ba, Th), and depletion in high field strength elements (HFSEs: Nb, Ta, Ti), as well as relatively high (La/Yb)N ratios represent the is-land arc TTG-like magmatism origin. Combine with the previous works, we suggest the Shiquanhe opiolitic mélange represent an island arc and back-arc assemblage rather than an independent ocean basin. Meanwhile, this Early Jurassic island arc magmatism initiated a new era of the Mesozoic mineralization in Shiquanhe area.