Radiomics is defined as the use of automated or semi-automated post-processing and analysis of multiple features derived from imaging exams. Extracted features might generate models able to predict the molecular profile of solid tumors. The aim of this study was to develop a predictive algorithm to define the mutational status of EGFR in treatment-naïve patients with advanced non–small cell lung cancer (NSCLC). CT scans from 109 treatment-naïve patients with NSCLC (21 EGFR-mutant and 88 EGFR-wild type) underwent radiomics analysis to develop a machine learning model able to recognize EGFR-mutant from EGFR-WT patients via CT scans. A “test–retest” approach was used to identify stable radiomics features. The accuracy of the model was tested on an external validation set from another institution and on a dataset from the Cancer Imaging Archive (TCIA). The machine learning model that considered both radiomic and clinical features (gender and smoking status) reached a diagnostic accuracy of 88.1% in our dataset with an AUC at the ROC curve of 0.85, whereas the accuracy values in the datasets from TCIA and the external institution were 76.6% and 83.3%, respectively. Furthermore, 17 distinct radiomics features detected at baseline CT scan were associated with subsequent development of T790M during treatment with an EGFR inhibitor. In conclusion, our machine learning model was able to identify EGFR-mutant patients in multiple validation sets with globally good accuracy, especially after data optimization. More comprehensive training sets might result in further improvement of radiomics-based algorithms. Significance: These findings demonstrate that data normalization and “test–retest” methods might improve the performance of machine learning models on radiomics images and increase their reliability when used on external validation datasets.

Stroke identification by means of microwave tomography requires a very accurate reconstruction of the dielectric properties inside patient's head. This is possible when a precise measurement system is combined with a full nonlinear inversion method. In this article, the inversion of S-parameter data collected in a metallic chamber is performed with a nonlinear inversion strategy in Lebesgue spaces with nonconstant exponents. This is the first time that this kind of nonlinear S-parameter electromagnetic formulation has been applied to this problem. The inverse-scattering method incorporates a 2-D electromagnetic model of the imaging chamber based on a finite-element formulation, which has led to a complete redefinition of the solving procedure with respect to previous works. This allows a suitable description of the multistatic S-parameters due to the interactions between the incident radiation and the structure under test. The developed inversion procedure is first assessed by means of numerical simulations. The experimental results, obtained with a clinical microwave system prototype containing a liquid-filled 3-D SAM phantom with an inhomogeneity mimicking a hemorrhagic stroke, further prove the effectiveness of the proposed approach.

A conjugate-gradient-based regularization technique in L ^p Banach spaces, in conjunction with an inexact-Newton solving scheme, is presented in this paper. The proposed method is applied to obtain the reconstruction of the dielectric properties of human tissues in hemorrhagic brain stroke microwave imaging. The dielectric reconstruction is obtained by solving a nonlinear inverse problem, starting from a set of scattered-field measurements. The presented numerical simulations with 2-D and 3-D anatomically realistic phantoms, as well as the preliminary experimental results, show that this method can be useful for retrieving the dielectric properties of the human head with a reduced over-smoothing effect in the final images.

In this article, a new microwave-radar-based technique for short-range detection and classification of multiple human and vehicle targets crossing a monitored area is proposed. This approach, which can find applications in both security and infrastructure surveillance, relies upon the processing of the scattered-field data acquired by low-cost off-the-shelf components, i.e., a 24 GHz frequency-modulated continuous wave (FMCW) radar module and a Raspberry Pi mini-PC. The developed method is based on an ad hoc processing chain to accomplish the automatic target recognition (ATR) task, which consists of blocks performing clutter and leakage removal with an infinite impulse response (IIR) filter, clustering with a density-based spatial clustering of applications with noise (DBSCAN) approach, tracking using a Benedict-Bordner $\alpha $ - $\beta $ filter, features extraction, and finally classification of targets by means of a $k$ -nearest neighbor ( $k$ -NN) algorithm. The approach is validated in real experimental scenarios, showing its capabilities in correctly detecting multiple targets belonging to different classes (i.e., pedestrians, cars, motorcycles, and trucks).

An electromagnetic inverse scattering approach for imaging of shallow subsurface objects is reported. It extends to multifrequency processing, an efficient method previously developed for single frequency imaging. The considered approach is an iterative procedure based on an inexact-Newton method developed in L Banach spaces, which exhibits effective regularization capabilities and reduced over-smoothing effects. The approach is validated using numerical simulations in which cylindrical scatterers are reconstructed in a homogeneous lossy medium. Results are compared with those obtained using standard single frequency operating conditions.