Background/Objectives: Arboviral diseases share common vectors, geographic distribution, and symptoms. Developing Machine Learning diagnostic tools for co-circulating arboviral diseases faces data-scarcity challenges. This study aimed to demonstrate that proof of concept using synthetic data can establish computational feasibility and guide future real-world validation efforts. Methods: We assembled a synthetic dataset of 28,000 records, with 7000 for each disease—Dengue, Zika, and Chikungunya—plus Influenza as a negative control. These records were obtained from the existing literature. A binary matrix with 67 symptoms was created for detailed statistical analysis using Odds Ratios, Chi-Square, and symptom-specific conditional prevalence to validate the clinical relevance of the simulated data. This dataset was used to train and evaluate various algorithms, including Multi-Layer Perceptron (MLP), Narrow Neural Network (NN), Quadratic Support Vector Machine (QSVM), and Bagged Tree (BT), employing multiple performance metrics: accuracy, precision, sensitivity, specificity, F1-score, AUC-ROC, and Cohen’s kappa coefficient. Results: The dataset aligns with the PAHO guidelines. Similar findings are observed in other arboviral databases, confirming the validity of the synthetic dataset. A notable performance across all evaluated metrics was observed. The NN model achieved an overall accuracy of 0.92 and an AUC above 0.98, with precision, sensitivity, and specificity values exceeding 0.85, and an average Uniform Cohen’s Kappa of 0.89, highlighting its ability to reliably distinguish between Dengue and Influenza, with a slight decrease between Zika and Chikungunya. Conclusions: These models could accelerate early diagnosis of arboviral diseases by leveraging encoded symptom features for Machine Learning and Deep Learning approaches, serving as a support tool in regions with limited healthcare access without replacing clinical medical expertise.

This work presents a synthetic binary database of Dengue, Zika, Chikungunya, and Influenza constructed entirely from clinical information extracted from the scientific literature. Due to the limited availability and heterogeneity of clinical records in medical units—particularly for arboviral diseases—existing datasets are often insufficient for developing robust Machine Learning models. To address this limitation, an extensive search of PubMed and Google Scholar was conducted between February 2024 and May 2025, following strict selection criteria focused on diagnostic confirmation. The resulting dataset comprises 48,214 records and 67 standardized signs and symptoms, homogenized across all pathologies. Each record is fully binary, contains no missing values, and represents symptom presence or absence. The composition includes 22,379 Dengue records, 7135 Zika records, 7959 Chikungunya records, and 10,741 Influenza records. Symptom prevalence was analyzed, revealing consistency with patterns reported in epidemiological and clinical studies, supporting the dataset’s plausibility. This database enables statistical exploration and direct integration into Machine Learning pipelines without the need for imputation. It has been used in an in silico predictive study of arboviral diseases, employing Influenza as a negative control, and serves as a reproducible, literature-derived resource for computational modeling.