To extend the drilling limit of horizontal sections, the demand for utilizing multiple hydraulic oscillators at intervals has become increasingly prominent. However, current research on the operating range of multiple oscillators, their mutual interference characteristics, and the impact of oscillation on drill string fatigue damage remains scarce. The results indicate that when the vibration ranges of multiple oscillators overlap, the overlapping segment experiences negative effects under identical excitation frequencies. If the oscillators operate at different frequencies, the displacement envelope of the drill string tends to become irregular. Within the normal amplitude range of oscillators, no significant fatigue damage is generally observed in adjacent sections of the drill string. However, when minor initial cracks exist in the drill string, an increase in oscillator amplitude leads to accelerated crack propagation, significantly hastening the fatigue failure process. In field operations, the parameters of multiple oscillators should be optimized according to specific working conditions, and timely non-destructive inspection of the drill string sections within the effective range of the oscillators must be conducted. The study provides novel insights into vibration wave propagation and fatigue damage in drill strings under multi-point excitation.