Prior radiomics studies have focused on two-class brain tumor classification, which limits generalizability. The performance of radiomics in differentiating the three most common malignant brain tumors (glioblastoma (GBM), primary central nervous system lymphoma (PCNSL), and metastatic disease) is assessed; factors affecting the model performance and usefulness of a single sequence versus multiparametric MRI (MP-MRI) remain largely unaddressed. This retrospective study included 253 patients (120 metastatic (lung and brain), 40 PCNSL, and 93 GBM). Radiomic features were extracted for whole a tumor mask (enhancing plus necrotic) and an edema mask (first pipeline), as well as for separate enhancing and necrotic and edema masks (second pipeline). Model performance was evaluated using MP-MRI, individual sequences, and the T1 contrast enhanced (T1-CE) sequence without the edema mask across 45 model/feature selection combinations. The second pipeline showed significantly high performance across all combinations (Brier score: 0.311–0.325). GBRM fit using the full feature set from the T1-CE sequence was the best model. The majority of the top models were built using a full feature set and inbuilt feature selection. No significant difference was seen between the top-performing models for MP-MRI (AUC 0.910) and T1-CE sequence with (AUC 0.908) and without edema masks (AUC 0.894). T1-CE is the single best sequence with comparable performance to that of multiparametric MRI (MP-MRI). Model performance varies based on tumor subregion and the combination of model/feature selection methods.

Despite the agricultural sector’s consistently high injury rates, formal reporting is often limited, leading to sparse national datasets that hinder effective safety interventions. To address this, our study introduces a comprehensive framework leveraging advanced ensemble machine learning (ML) models to predict and interpret the severity of agricultural injuries. We use a unique, manually curated dataset of over 2400 agricultural incidents from AgInjuryNews, a public repository of news reports detailing incidents across the United States. We evaluated six ensemble models, including Gradient Boosting (GB), eXtreme Grading Boosting (XGB), Light Gradient Boosting Machine (LightGBM), Adaptive Boosting (AdaBoost), Histogram-based Gradient Boosting Regression Trees (HistGBRT), and Random Forest (RF), for their accuracy in classifying injury outcomes as fatal or non-fatal. A key contribution of our work is the novel integration of explainable artificial intelligence (XAI), specifically SHapley Additive exPlanations (SHAP), to overcome the “black-box” nature of complex ensemble models. The models demonstrated strong predictive performance, with most achieving an accuracy of approximately 0.71 and an F1-score of 0.81. Through global SHAP analysis, we identified key factors influencing injury severity across the dataset, such as the presence of helmet use, victim age, and the type of injury agent. Additionally, our application of local SHAP analysis revealed how specific variables like location and the victim’s role can have varying impacts depending on the context of the incident. These findings provide actionable, context-aware insights for developing targeted policy and safety interventions for a range of stakeholders, from first responders to policymakers, offering a powerful tool for a more proactive approach to agricultural safety.