The paper proposes an intelligent energy management system designed for a university laboratory room, centered on the user and based on the integration of smart sensors and fuzzy logic for the simultaneous optimization of thermal comfort and energy efficiency. The system architecture integrates three control methods, On/Off controller, Proportional Integral Derivative (PID) controller, and Fuzzy Logic, within a hybrid structure capable of managing multiple factors such as thermal comfort, energy consumption, and the availability of renewable energy sources. The system is implemented and tested using Zigbee 3.0 sensors, smart relays, and photovoltaic panels, while variables such as temperature, humidity, energy consumption, and user feedback are monitored. The simulation results, obtained in the MATLAB/Simulink development environment, demonstrate that the fuzzy algorithm reduces thermal oscillations, optimizes energy costs, and maintains perceived comfort within an optimal range. The main contribution of the study lies in the development of a user-centered, interpretable, and scalable architecture, along with a PowerApps application that records occupants’ feedback in real time, which can be implemented in smart buildings with limited computational resources. Two operating scenarios with different time periods were developed for the proposed system. The fuzzy controller maintained a mean temperature deviation below ±0.2 °C, reduced oscillatory behavior compared to PID controller, and enabled photovoltaic coverage of up to 29.97% during peak intervals, with an average daily contribution of 8.77%. The total simulated energy cost was 8.49 RON for the one-day scenario and 48.12 RON for the five-day interval.