The conventional reactive cooling strategy, which relies on static thresholds, has become inadequate for managing dynamically changing heat loads, often resulting in energy inefficiency and increased risk of local hot spots. In this study, we develop a data center cooling optimization system that integrates distributed sensor arrays for predictive analysis. By deploying high-density temperature and humidity sensors both inside and outside server racks, a real-time, high-fidelity three-dimensional digital twin of the data center’s thermal environment is constructed. Time-series analysis combined with Long Short-Term Memory algorithms is employed to forecast temperature and humidity based on the extensive environmental data collected, achieving high predictive accuracy with a root mean square error of 0.25 and an R² value of 0.985. Building on these predictions, a proactive cooling control strategy is formulated to dynamically adjust fan speeds and the opening degree of chilled-water valves in computer room air conditioning units, changing the cooling approach from passive to preemptive prevention of overheating. Compared with conventional proportional–integral–differential control, the developed system significantly reduces overall energy consumption and maintains all equipment within safe operating temperatures. Specifically, the framework has reduced the energy consumption of the cooling system by 37.5%, lowered the overall power usage effectiveness of the data center by 12% (1.48 to 1.30), and suppressed the cumulative hotspot duration (temperature 27 °C) by nearly 96% (from 48 to 2 h).