Mixed traffic flow composed of connected and automated vehicles (CAVs) and human-driven vehicles (HDVs) represents a core characteristic of intelligent transportation systems. However, its operational efficiency is significantly constrained by lane management strategies and CAV cooperative driving behaviors. To investigate this, a cellular automata-based simulation model is developed that integrates multiple car-following rules, a lane-changing strategy, and a platoon coordination mechanism. Through a systematic comparison of 13 lane management strategies in one-way two-lane and three-lane configurations, this study analyzes the influence mechanisms of lane allocation and cooperative driving on traffic flow, considering fundamental diagram characteristics, operating speed, CAV degradation behavior, and maximum platoon size. The results indicate that the performance of different strategies exhibits phased evolution with increasing CAV penetration rates. At low penetration rates, providing relatively independent space for HDVs effectively suppresses random disturbances and improves throughput. At medium to high penetration rates, dedicated CAV lanes—especially those with spatial continuity—enable cooperative platoons to fully leverage their advantages, leading to significant improvements in traffic capacity and operational stability. These findings demonstrate an optimal alignment between cooperative driving mechanisms and lane configurations, offering theoretical support for highway lane management in mixed traffic environments.