Recent advances in coumarin-based anticancer agents.

Spiro heterocycle frameworks are a class of organic compounds that possesses unique structural features making them highly sought-after targets in drug discovery due to their diverse biological and pharmacological activities.

Tetronic acid, a versatile synthon, has been extensively investigated by numerous researchers in synthetic chemistry due to its crucial role in synthesizing heterocycles which makes this compound particularly advantageous in both pharmaceutical and biological fields. Various heterocycles can be synthesized using it as a precursor via multicomponent reactions (MCRs). Dicarbonyl groups can be considered the building blocks and key structural motifs of a wide range of natural compounds, which may contain different functional groups in the synthesis of heterocyclic frameworks. This review covers the literature from 2017 to 2022, and it encompasses the different one-pot protocols for synthesizing a variety of heterocyclic molecules.

In terms of pharmaceuticals and biological applications, synthesis of complex organic molecules is a significant and fast‐developing area. In this context, organic electrosynthesis is an alternative way to the traditional methods for chemo‐, regio‐, and stereoselective syntheses. Electro‐organic reactions occur at room temperature and normal pressure, through transferring electrons. It has been found that electrosynthesis is a mild approach for preparing electrophilic substrates, bases, and nucleophiles in situ, from highly stable and low‐level reagents; which can be further applied to make heterocycles more accessible. While several promising methods exist, multi‐component reactions (MCRs) have drawn much attention both in academia and industry worldwide, since they are cost‐efficient and environmentally friendly. Combining the electrosynthesis and MCRs has produced a great strategy in the field of organic synthesis for industry and research. This review focuses on recent advances in the electrochemical synthesis of heterocyclic compounds via multi‐component reactions, reported between 2015 and March 2023.

Heterocycles are a vital class of compounds in numerous fields, including drug discovery, agriculture, and materials science. Efficient methods for the synthesis of heterocycles remain critical for meeting the demands of these industries. Recent advances in multicomponent reactions (MCRs) utilizing 2‐aminobenzothiazole (ABT) have shown promising results for the formation of heterocycles. The versatility of 2‐aminobenzothiazole in this context has enabled the rapid and efficient construction of diverse heterocyclic structures. Various synthetic methodologies and reactions involving 2‐aminobenzothiazole are discussed, highlighting its importance as a valuable building block in the synthesis of complex heterocycles. The potential applications of these heterocycles in drug discovery and material science are also explored. Overall, this review provides a comprehensive overview of the current state of research in the field and offers insights into the future directions of this promising area of study. We highlight the potential of ABT as a versatile and sustainable starting material in heterocyclic synthesis via MCRs, with significant implications for the chemical industry.