The CoCrMo alloys are progressively utilized as biomaterials. This research is dedicated to studying the consequence of (1, 3, and 5) wt% nano-TiO₂ addition on the porosity, microstructure, microhardness, and wear behavior of pre-alloyed CoCrMo powder produced by powder metallurgy (PM). Microstructural features were examined using SEM, SEM mapping, and XRD. Wear behavior was assessed through pin-on-disk tests performed under dry sliding conditions at varying loads and durations. Porosity increased with the addition of nano-TiO₂, from 15.26 at 0 wt% reaching 25.12% at 5 wt%, while density decreased from 7.16 to 6.33 g/cm³. Microhardness exhibited a slight improvement, attaining 348 HV at 5 wt%. SEM and XRD analyses confirmed partial particle separation after sintering and identified the TiO₂ reinforcement as rutile. Wear tests revealed that adding 1 wt% nano-TiO₂ enhanced wear resistance, whereas extended sliding durations resulted in increased wear rates. Adhesive wear was the predominant mechanism, accompanied by limited abrasive wear, oxidation, and plastic deformation.