Background: The aim of this study was to evaluate the diagnostic and prognostic performance of albumin-based inflammatory–nutritional indices in hyperemesis gravidarum (HG) and to determine their associations with disease severity and risk of re-hospitalization. Methods: This retrospective case–control study included 246 women with HG and 246 gestational-age-matched healthy pregnant controls at 6–16 weeks of gestation. Disease severity was classified as mild, moderate, or severe using the Pregnancy-Unique Quantification of Emesis (24 h scale) (PUQE-24) score. A comprehensive panel of albumin-based inflammatory indices—including C-reactive protein-to-albumin ratio (CAR), fibrinogen-to-albumin ratio (FAR), neutrophil-to-albumin ratio (NAR), leukocyte-to-albumin ratio (LAR), neutrophil percentage-to-albumin ratio (NPAR), monocyte-to-albumin ratio (MAR), hemoglobin–albumin–lymphocyte–platelet (HALP) score, modified HALP (m-HALP) score, prognostic nutritional index (PNI) score, systemic immune-inflammation index-to-albumin (SII/Alb), and systemic inflammatory response index-to-albumin (SIRI/Alb)—was calculated from routine complete blood count and serum biochemistry results obtained at diagnosis. Receiver operating characteristic analysis, along with univariate and multivariate logistic regression models, was performed to evaluate diagnostic performance and identify predictors of severe HG and re-hospitalization. Results: Albumin-based indices exhibited severity-associated alterations, with an overall trend toward worsening immuno-nutritional status across increasing HG severity. Among these, m-HALP score demonstrated the strongest inverse correlations with PUQE-24 score, ketonuria grade, length of hospital stay, and re-hospitalization risk (r = −0.74 to −0.52; all p < 0.001) and achieved the highest discriminative accuracy for both severe HG (AUC 0.864, 95% CI 0.836–0.892, p < 0.001) and re-hospitalization (AUC 0.722, 95% CI 0.675–0.766, p < 0.001). In multivariable analysis, higher HALP, m-HALP, and PNI were independently associated with a lower likelihood of severe HG. For re-hospitalization, higher m-HALP and HALP were independently associated with a lower risk, whereas higher NPAR, higher ketonuria grade, and higher PUQE-24 score were independently associated with an increased risk of re-hospitalization. Conclusions: Albumin-based indices, particularly m-HALP, demonstrated robust diagnostic and prognostic performance in HG compared with conventional biomarkers. These readily available, cost-neutral composite biomarkers enable objective severity stratification and accurate identification of patients at elevated risk of recurrent hospitalization, offering immediate potential to guide personalized, evidence-based clinical management.

Aims: Influenza infection is a significant cause of mortality and morbidity in pregnant women and newborns. Therefore, annual influenza vaccination is strongly recommended for pregnant women during any trimester during the influenza season. The aim of this study is to determine vaccination rates in pregnant individuals at risk for influenza infection and to determine the reasons for not being vaccinated in those who are not vaccinated. Methods: The study was conducted as a cross-sectional survey study on pregnant women aged 18-45 in the first, second and third trimesters who applied to the Health Sciences University Ankara Training and Research Hospital Gynecology and Obstetrics Clinic between November 2023 and April 2024. The researchers reviewed the relevant literature and prepared a survey consisting of 19 questions to be administered to the participants. Results: The mean age of the pregnant women included in the study was 25.66±5.2 (18-42) years, and the mean gestational age was 26.02±5.8 weeks (minimum 2 weeks - maximum 40 weeks).Of the participants, 334 (83.5%)did not believed that the flu vaccine was protective. 66 (16.5%) believe that it was protective.A doctor had recommended the flu vaccine to 229 (57.3%) of the participants. The concern that the flu vaccine might be harmful to the baby was the most important r eason for not getting flu vaccinated. Conclusion: Tables prepared for educational purposes make it possible to quickly and easily exchange information about vaccination between doctors and pregnant women. For this reason, influenza vaccination is an important part of pre-pregnancy, pregnancy and postpartum care. Gynecologists and obstetricians, family physicians; should recommend influenza vaccination to pregnant women and increase the vaccination rate of pregnant women. We believe that this approach will benefit the pregnant woman and the newborn.

Fetal ultrasonografi doğum öncesi bakımın bir parçası olarak görülmekle birlikte sıklıkla ilk üç ayda yapılması önerilmektedir. Genel olarak fetusun ultrasonografiyle incelenmesinin amacı en uygun doğum öncesi bakımın sağlanması ve fetüsün erken dönemdeki gelişimini belirlemektir. Down sendromu canlı doğumlarda en sık rastlanan kromozomal anomalidir ve yaklaşık olarak 1/1000 oranında görülmektedir. Gebe takiplerindeki temel amaç; fetüste meydana gelebilecek olan hastalıkları takip etmek ve bu hastalıklarla ilgili aileye gereken durumlarda genetik danışmanlık vermektir.