The digital and ecological transition of the industrial sector requires methodological tools that integrate information modelling, performance simulation, and operational decision support. In this context, the present study introduces and tests a semi-automatic BIM-to-BEM framework to optimise human–machine interaction and support critical data interpretation through Graphical User Interfaces. The objective is to propose and validate a BIM-to-BEM workflow for an existing industrial facility to enable comparative evaluation of energy retrofit scenarios. The information model, developed through an interdisciplinary federated approach and calibrated using parametric procedures, was exported in the gbXML format to generate a dynamic, interoperable energy model. Six simulation scenarios were defined incrementally, including interventions on the building envelope, Heating, Ventilation and Air Conditioning (HVAC) systems, photovoltaic production, and relamping. Results are made accessible through dashboards developed with Business Intelligence tools, allowing direct comparison of different design configurations in terms of thermal loads and indoor environmental stability, highlighting the effectiveness of integrated solutions. For example, the combined interventions reduced heating demand by up to 32% without compromising thermal comfort, while in the relamping scenario alone, the building could achieve an estimated 300 MWh reduction in annual electricity consumption. The proposed workflow serves as a technical foundation for developing an operational and evolving Digital Twin, oriented toward the sustainable governance of building–system interactions. The method proves to be replicable and scalable, offering a practical reference model to support the energy transition of existing industrial environments.