Background: Eosinophilic gastrointestinal disorders (EGIDs) are a rare group of inflammatory disorders that can occur anywhere along the gastrointestinal tract, from the esophagus to the rectum. In particular, those with malignant or benign tumors are extremely rare. Case presentation: A 62-year-old man was referred to our hospital with a chief complaint of abdominal fullness. The peripheral white blood cell count was 19,400/µL, and the eosinophil count was 13,300/µL. Abdominal computed tomography showed massive ascites. Cytology of the ascitic fluid showed a large amount of eosinophils and no malignancy. Upper and lower gastrointestinal endoscopies were performed on the suspicion of EGIDs, and colon cancer with no other abnormalities was found. The biopsies of the cancer lesions and non-cancer lesions also showed significant differences in eosinophil counts per high-power field (HPF) between the cancer and non-cancer lesions (median 77.5 [IQR 52–115] vs. 40.5 [35–56]/HPF, P < 0.05). Exploratory laparoscopy showed cloudy massive ascites and thickening of the mesentery. Pathological examination of the mesentery showed a large amount of eosinophils (median 177.5 [IQR 91–227]/HPF) and no malignancy. Based on these findings, it was suspected that the massive ascites due to eosinophilic peritonitis could be associated with colon cancer. Steroid administration resulted in immediate disappearance of the ascites, and laparoscopic left hemicolectomy was safely performed 6 weeks after steroid administration. Conclusion: This report presented a case of eosinophilic peritonitis that could be related to colon cancer. Exploratory laparoscopy was useful to detect the cause of ascites. The possibility that eosinophilic peritonitis was associated with colon cancer is discussed based on the histopathological findings.

Static cold storage remains the most widely used method for organ preservation in transplantation. Over time, preservation solutions have undergone continuous optimization. Ecosol is a novel extracellular-type, colloid-based preservation solution. In this study, we evaluated the safety and efficacy of Ecosol in comparison to the gold standard University of Wisconsin (UW) solution using both allogeneic and syngeneic rat orthotopic liver transplantation models. Liver function parameters were assessed and compared to baseline values of the respective rat strains. In the syngeneic setting, alanine transaminase (ALT) levels were significantly higher in the UW group than in the Ecosol group on day 1 post-transplantation (p < 0.05). Lactate dehydrogenase (LDH) levels were significantly elevated in the UW group compared to Ecosol in both allogeneic and syngeneic models on day 1 (p < 0.001). Gamma-glutamyl transferase (GGT) and total bilirubin were also significantly higher in the UW syngeneic group on day 1 (p < 0.05). In the allogeneic setting, aspartate aminotransferase (AST) and ALT levels were significantly elevated in both the UW (p < 0.0001) and Ecosol (p < 0.0001 and p < 0.001, respectively) groups on day 1 compared to the baseline values of Brown Norway (BN) rats. On day 7, these elevations persisted in the UW group, whereas no significant differences were observed in the Ecosol group compared to the baseline BN values (UW vs. Ecosol: p < 0.0001). In syngeneic transplants, AST and ALT levels were significantly elevated in both groups on day 1 compared to the baseline values of Lewis rats (p < 0.0001). By day 7, AST levels remained significantly elevated in the UW group, while Ecosol showed no significant difference from baseline (p < 0.0001). Organ viability, assessed via non-invasive imaging after 8 h of cold storage, was improved with Ecosol. Overall, Ecosol demonstrated biological safety and non-inferiority to the UW solution for liver preservation in a rat orthotopic liver transplantation model.