By integrating genomics and epigenetics from the concept of central dogma vs. paracentral dogma (Wang, 2023a; Wang, 2023b), we could account for both genetic predisposition and environmental influences on disease development. In precision medicine, syndrome differentiation plays a crucial role in disease diagnosis and treatment (Dai et al., 2022). Exploring therapeutic strategies to specific syndromes enables more effective disease management. The incorporation of symptomatology and customized prescriptions contributes significantly to the advancement of precision medicine. We are proud to showcase four featured publications in this Research Topic entitled "Application of Genomics and Epigenetics in Disease and Syndrome Classification". This editorial aims to provide a concise overview of these articles and highlight their significant contributions to the field. Genomic studies play a pivotal role in identifying genetic variations associated with diseases. Notably, genome-wide association studies have unveiled single nucleotide polymorphisms (SNPs) associated with specific diseases (Wang et al., 2023). In this Research Topic, Liu et al. found that miR-196a2 rs11614913 and miR-27a rs895819 may influence genetic susceptibility to gastric precancerous lesions (GPL) or gastric cancer (GC). Additionally, they revealed a synergistic effect between miR-196a2 rs11614913 and Helicobacter pylori infection in the onset and progression of GPL. A similar study previously indicated that pri-miR-124-1 rs531564 and STAT3 rs1053023 are associated with a higher risk of GC (Mirnoori et al., 2018). These studies demonstrated that SNPs of miRNAs could be significantly associated with