Luis Pardo

Dr. Luis Pardo

Max-Planck-Institut für experimentelle Medizin, AG Oncophysiology, Göttingen, Germany
orcid

Research Focus & Metrics

Academic Career Length

38Years (1989-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 December 2005 in Pharmacological Reviews
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Journal Article
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GGGeorge A. Gutman
George A. Gutman
KCK. George Chandy
K. George Chandy
SGStephan Grissmer
Stephan Grissmer
MLMichel Lazdunski
Michel Lazdunski
DMDavid Mckinnon
David Mckinnon
XWXiaoliang Wang
Xiaoliang Wang

1 December 2009 in Nature Reviews Drug Discovery
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Journal Article
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HWHeike Wulff
Heike Wulff
NCNeil A. Castle
Neil A. Castle
Luis PardoLuis Pardo
Luis Pardo

12 December 2013 in Nature Reviews Cancer
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Journal Article
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Luis PardoLuis Pardo
Luis Pardo
WSWalter Stühmer
Walter Stühmer

15 October 1999 in The EMBO Journal
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Journal Article
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Luis PardoLuis Pardo
Luis Pardo
DCDonato del Camino
Donato del Camino
ASAraceli Sánchez
Araceli Sánchez
FAFrauke Alves
Frauke Alves
ABAndrea Brüggemann
Andrea Brüggemann
WSWalter Stühmer
Walter Stühmer
We have investigated the possible implication of the cell cycle‐regulated K+ channel ether à go‐go (EAG) in cell proliferation and transformation. We show that transfection of EAG into mammalian cells confers a transformed phenotype. In addition, human EAG mRNA is detected in several somatic cancer cell lines, despite being preferentially expressed in brain among normal tissues. Inhibition of EAG expression in several of these cancer cell lines causes a significant reduction of cell proliferation. Moreover, the expression of EAG favours tumour progression when transfected cells are injected into immune‐depressed mice. These data provide evidence for the oncogenic potential of EAG.

19 March 2014 in Philosophical Transactions of the Royal Society B: Biological Sciences
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Open access
DUDiana Urrego
Diana Urrego
ATAdam P. Tomczak
Adam P. Tomczak
FZFarrah Zahed
Farrah Zahed
WSWalter Stühmer
Walter Stühmer
Luis PardoLuis Pardo
Luis Pardo
Normal cell-cycle progression is a crucial task for every multicellular organism, as it determines body size and shape, tissue renewal and senescence, and is also crucial for reproduction. On the other hand, dysregulation of the cell-cycle progression leading to uncontrolled cell proliferation is the hallmark of cancer. Therefore, it is not surprising that it is a tightly regulated process, with multifaceted and very complex control mechanisms. It is now well established that one of those mechanisms relies on ion channels, and in many cases specifically on potassium channels. Here, we summarize the possible mechanisms underlying the importance of potassium channels in cell-cycle control and briefly review some of the identified channels that illustrate the multiple ways in which this group of proteins can influence cell proliferation and modulate cell-cycle progression.

3 September 2013 in Molecular Psychiatry
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CHC Hammer
C Hammer
BSB Stepniak
B Stepniak
ASA Schneider
A Schneider
SPS Papiol
S Papiol
MTM Tantra
M Tantra
HEHannelore Ehrenreich
Hannelore Ehrenreich