Helicobacter pylori (H. pylori) infection is one of the most common bacterial infections worldwide. Its role in infection-associated cancers, such as gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma is well known. However, mitochondrial alterations in these malignancies are less documented. Mitochondria are key organelles, maintaining cellular homeostasis under normal and pathological conditions. They regulate complex cellular processes and play a key role in carcinogenesis and cancer progression in H. pylori-associated malignancies. This review summarizes the role of mitochondrial stress in H. pylori infection, gastric cancer, and MALT lymphoma.

Helicobacter pylori (H. pylori) infection is recognized as one of the most common bacterial infections worldwide. Its role in infection-associated cancers, such as in gastric cancer and MALT-lymphoma, is well known. Mitochondrial alterations in these malignancies are less documented. Mitochondria is a key organelle in maintaining cellular homeostasis under normal and pathological conditions. They regulate complex cellular processes, and they are key players in carcinogenesis and cancer progression in these H.pylori-associated malignancies. In this review, we summarize the role of mitochondrial stress in H. pylori infection, in gastric cancer, and MALT-lymphoma.