Cancer is a complex, multifactorial disease that modern medicine ultimately aims to overcome. Downstream of tyrosine kinase 2 (DOK2) is a well-known tumor suppressor gene, and a member of the downstream protein DOK family of tyrosine kinases. Through a search of original literature indexed in PubMed and other databases, the present review aims to extricate the mechanisms by which DOK2 acts on cancer, thereby identifying more reliable and effective therapeutic targets to promote enhanced methods of cancer prevention and treatment. The review focuses on the role of DOK2 in multiple tumor types in the lungs, intestines, liver, and breast. Additionally, we discuss the potential mechanisms of action of DOK2 and the downstream consequences via the Ras/MPAK/ERK or PI3K/AKT/mTOR signaling pathways.

Location of the proteases would affect on protease stability and photorespiratory bypass pathway, while it is unsolved. Potato rbcS signal peptide was analyzed and constructed into the protease for study of their localization site. The tartronate semialdehyde reductase (EcTSR) proteins could be accurately and efficiently located in chloroplast only when this signal peptide was extended to 80 amino acids. The signal peptide would help malate synthase (CmMS) locate to the surface of chloroplast, to form granules on the outer membrane of chloroplast. The whole spectrum scanning showed that these proteins could enter chloroplast. A signal peptide named PCS1 (Peptide of self-cleavage site 1) carrying a self-cleavage site was designed, and sixteen amino acids from the blue pigment precursor protein of chloroplast positioning signal of Silene pratensis were added to the C-terminal of PCS1. Transient expression, Western blot analysis and full-spectrum scanning showed that PCS1 could locate the EcTSR to the chloroplast, after the removal of the signal peptide.

With the deepening of reform and opening up, the continuous improvement of comprehensive national strength and international influence, the enrollment of international students continues to expand, and the education of international students has become an important part of China's higher education. Combined with the problems existing in the pharmacology experiment teaching of international students in our university and their own characteristics, this paper introduces the online and offline mixed teaching mode into the pharmacology experimental teaching of international students, in order to improve the experimental teaching effect and provide useful reference for the guarantee of teaching quality of international students.

Medical experiment teaching is the basic link of medical education and an important way to train medical students' practical ability and innovative spirit. In recent years, with the continuous development of medical education reform, the teaching reform of functional experiment has become the focus of attention. Based on the basic framework of the 5-year experimental teaching content of functional experiment for students majoring in clinical medicine, this paper carries out the teaching reform of "three integration, three connection and three evaluation" of the experimental course of kinesiology based on the core literacy training of medical students of different majors and levels, and probes into the implementation process and effect of the teaching reform. The practice shows that teaching reform has played a good role in promoting the cultivation of medical students' practical ability, innovative ability and core quality.