Introduction: Facial beauty mostly depends on the correct mutual relations of the upper and lower jaw, along with the jaw and teeth, which results in different convexity and shape of the lips, causing the unique morphology of an individual's lips. Aim: The research aims were to determine the morphometric differences of the horizontal position of the lips concerning the reference lines (Ricketts, Steiner, Burstone, Sushner line and Merrifield angle) and sex of the subjects. Material and methods: The research was conducted on 60 subjects (30 males/30 females), students of the Faculty of Medicine University of Novi Sad, ages 18 to 20. Facial profile photos of each subject were taken in the Frankfurt plain position. After marking the reference lines in the Paint program, measurements were performed using the program ImageJ 1.48v. Results: The average distance of the upper and lower lip from the Ricketts line in males was 7.48/5.42mm, in females 5.82/3.87mm; from the Steiner line in men was 2.80/2.49mm, in females 1.99/2.21mm; from the Burstone line in males was 2.48/2.14mm, in females 2.88/2.38mm; from the Sushner line in males was 6.06/3.73mm, in females 6.50/4.31 mm; the average value of the Merrifield angle in males was 71.51°, and in females 69.57°. Conclusion: No "ideal position" of the lips concerning two or more reference lines was determined in any of the subjects. Therefore, based on these data, it is difficult to determine what is "ideal" precisely because there are several lines that are prescribed by different norms. The results of our research largely correspond to the results found in the literature.

Objective: The aim of this study was to evaluate the impact of chronic kidney disease (CKD) on clinical presentation, laboratory parameters, ECG, and echocardiographic features of patients with chronic heart failure (CHF). Methods: This retrospective cross-sectional study included 2227 patients hospitalized in a tertiary care center due to CHF. Patients were divided into two groups based on the presence of CKD, defined as eGFR < 60 mL/min/1.73 m². Demographic, clinical, laboratory, and echocardiographic data were collected for all patients. Comparative analyses were performed to assess differences in cardiovascular risk factors, comorbidities, laboratory parameters, and echocardiographic findings between the two groups. Results: The proportion of men was significantly higher in the non-CKD group, whereas women predominated in the CKD group (p < 0.001). Dyspnea, orthopnea, leg swelling, claudication, and expectoration were significantly more frequent in patients with CKD, while chest pain and palpitations were more common in the non-CKD group (all p < 0.05). A significant difference in the distribution of NYHA functional classes was observed between the groups (p < 0.001), with NYHA class IV being more prevalent in the CKD group and classes II and III more frequent in the non-CKD group. Levels of CRP and NT-proBNP were significantly higher in the CKD group (p < 0.001). In-hospital mortality was 2.5-fold higher in patients with CKD (28.6% vs. 11.1%; p < 0.001). Conclusions: Coexistence of CKD was associated with a more severe clinical presentation, advanced functional limitation, and a distinct laboratory and echocardiographic profile in CHF patients.