Mulched drip irrigation for maize cultivation has been widely implemented in the Xiliao River Plain in Northeast China in recent years. However, the effects of the change in irrigation method on soil water content and groundwater recharge in this area still remains uncertain. In this study, soil water content under mulched drip irrigation and flood irrigation was measured through field experiments. Soil water movement in the entire growing season under the two irrigation methods was simulated for the quantitative analysis of groundwater recharge by the Hydrus-2D model. Results showed that soil water content under mulched drip irrigation was generally larger than that of flood irrigation in the initial growth stage. However, an opposite trend was observed in the main growth stage. The simulated results indicated that the cumulative water fluxes of flood irrigation were greater than the values of mulched drip irrigation. Moreover, while infiltration depth under flood irrigation reached the maximum simulated depth (400 cm), infiltration depth under mulched drip irrigation was only 325 cm. The results of this study showed that mulched drip irrigation reduced the infiltration depth and groundwater recharge to some extent in the Xiliao River Plain. Such results are helpful in determining the influence of mulched drip irrigation on groundwater and can be a reference for the maintenance of the sustainability of regional groundwater in the large-scale promotion of mulched drip irrigation.