Bound states in the continuum (BICs) can be transformed into quasi-bound states (quasi-BICs) via intentional symmetry breaking, thereby enabling ultrahigh-Q resonances critical for refractometric sensing applications. To advance detection capabilities for organic analytes, we proposed an all-dielectric metasurface monolithically integrated within a microfluidic channel. Mirror symmetry was intentionally disrupted through a cylindrical perturbation applied to one of two identical elliptical resonators, which excited a quasi-BIC mode at 1.9591 THz with a numerically validated Q-factor of 1959. This resonance manifested an absorption peak approaching unity, featuring a full-width at half-maximum (FWHM) of merely 1 GHz. Multipolar decomposition revealed that the mode originated from a synergistic electric-quadrupole (EQ)–magnetic-dipole (MD) pair, wherein the EQ contribution exceeded the MD counterpart by 20%. Capitalizing on this high-Q resonance, the sensor attained a sensitivity of 240 GHz per refractive-index unit (GHz RIU⁻¹) and a figure of merit (FOM = S/FWHM) of 240, while demonstrating robust performance against fabrication tolerances spanning −4% to +4%. Additionally, we verified that oblique-incidence illumination could activate a quasi-BIC within the identical spectral band, circumventing the need for structural asymmetry and thus expanding operational versatility. Benefiting from its geometric simplicity and competitive performance, this architecture exhibited substantial potential for on-chip sensing of organic compounds.

Conventional quasi-bound state in the continuum (quasi-BIC) terahertz (THz) metasurfaces usually operate at fixed resonance frequencies and lack electrically controlled dynamic tunability. To address this limitation, we propose two schemes for realizing liquid-crystal-integrated quasi-BIC THz metasurfaces by exploiting the electrically tunable refractive index of liquid crystals in the THz regime. A microfluidic multilayer architecture combining a liquid-crystal functional layer with a silicon (Si)-based metasurface is constructed, in which the transition from an ideal BIC to a quasi-BIC is realized through two distinct mechanisms: pixelated control of the liquid-crystal orientation and geometric symmetry breaking of the Si resonators. Cartesian multipole decomposition reveals that the resonances in both configurations are dominated by magnetic dipole modes. The effects of the liquid-crystal orientation angle and key geometric parameters on the resonance frequency, peak absorptance, and quality factor are systematically investigated. Numerical results demonstrate continuous tuning of the terahertz resonance through variation in the liquid-crystal orientation angle, corresponding to electrically driven liquid-crystal reorientation in practical devices. The sensing performance of the optimized Si-resonator-based configuration is further evaluated, achieving a refractive index sensitivity of 117 GHz RIU⁻¹ and a figure of merit (FOM) of 146.25. This work overcomes the fixed-frequency limitation of conventional static quasi-BIC metasurfaces and provides a feasible route toward electrically reconfigurable terahertz microfluidic sensing devices with tunable operating frequencies.