Sugar cane bagasse (SCB) is an abundant byproduct of sugar and bioethanol mills. It has been effectively used as a low-cost biosorbent to remove hazardous chemical compounds from a variety of effluent sources. Herein, we report on the preparation of SCB and its use as a solid phase extraction (SPE) sorbent to retain synthetic hormones (ethinylestradiol, drospirenone, and levonorgestrel) from industrial pharmaceutical plant effluent samples prior to LC–MS/MS quantitative analysis. We evaluated the reproducibility and recoveries and accuracy data analyses were compared with that of commercial SPE (cSPE) cartridges. The results from the evaluated parameters indicated that the SCB bed had an efficiency of >99%, comparable to that of cSPE cartridges, demonstrating the applicability and feasibility of this material as an effective and green chemistry alternative, as well as its biosorbent potential to remove hormones from industrial pharmaceutical effluent.

This study evaluates the bioadsorption efficiency of sugarcane bagasse (SCB) for removing pharmaceuticals and illicit drugs—such as acetaminophen, atenolol, caffeine, carbamazepine, diclofenac, orphenadrine, losartan, enalapril, citalopram, cocaine, and benzoylecgonine—from wastewater effluents. In Brazil, where 46% of the population lacks access to sewage systems, and over 5.3 billion pharmaceutical packages are consumed annually, untreated discharges contribute significantly to aquatic contamination. Results show that applying SCB biochar at a 1% (m/v) ratio removes up to 99.8% of these compounds at total concentrations of 140 ng mL⁻¹, reducing the ecological risk from high to low for caffeine and losartan. SCB offers several advantages as a bioadsorbent: it is abundant, non-toxic, inexpensive, easy to handle, and exhibits high adsorption capacity and rapid kinetics across a wide range of chemical polarities. These findings highlight SCB’s potential as a sustainable and efficient material for wastewater treatment applications.