Background and Objectives: In real-world NSCLC management, prognostic assessment extends beyond tumour staging and molecular profiling, which represent a partial timeframe of disease biology. Routinely collected inflammatory and haematological markers may better reflect the dynamic host–tumour interactions during treatment. This study assessed the prognostic significance of baseline and longitudinal neutrophil-to-lymphocyte ratio (NLR) and haemoglobin levels on survival outcomes in a real-world NSCLC cohort. Materials and Methods: We conducted a retrospective observational cohort study of 615 patients with histologically confirmed NSCLC diagnosed between 1 May 2022 and 30 April 2024 at a tertiary referral centre in western Romania. Survival outcomes, including progression-free and overall survival, were analysed through Kaplan–Meier curves, complemented by 12-month restricted mean survival time estimates. High NLR was defined as ≥3 and low haemoglobin as <12 g/dL. Longitudinal changes were evaluated at 6 and 12 months, with 12-month analyses restricted to patients alive at that landmark. Results: The cohort had a median age of 66 years (IQR 60–72) and was predominantly male (66.3%). Most patients presented with advanced disease (60.3% stage IV, 23.6% stage III). At baseline, 57.1% (n = 351) exhibited high NLR and 39.8% (n = 245) had low haemoglobin. Median PFS was 9.0 months (IQR 4.5–15.5), and median OS was 16.5 months (IQR 8.5–27.0). Stage IV disease was associated with shorter PFS than stages I–II (7.0 vs. 20.8 months; log-rank p < 0.001). High-baseline NLR showed a borderline association with shorter PFS (adjusted HR 1.40; 95% CI 0.98–1.95). Among the 436 patients alive at 12 months, NLR increased in 56.7% of cases, and this increase showed a non-significant trend toward shorter PFS (HR 1.35; 95% CI 0.95–1.90; p = 0.09) in a 12-month landmark analysis. Conclusions: Baseline systemic inflammation and anaemia are highly prevalent in real-world NSCLC patients and cluster with advanced disease. Elevated NLR was associated with poorer survival outcomes, whereas low haemoglobin did not demonstrate a significant independent association in adjusted analyses. These haematological parameters are accessible tools for prognostic assessment in routine clinical practice.

Pleomorphic adenomas (PAs) are benign mixed tumors of the salivary glands that usually present with morphological characteristics consisting of epithelial and myoepithelial cells and a chondromyxoid stromal component. Atypical cells; squamous, osseous, lipomatous, endocrine-like or apocrine metaplasia; aspects of invasion (vascular, perineural, in adjacent tissues or the capsule); necrosis; and unusual dimensions were reported as uncommon aspects that can be encountered in PAs. This study consisted of a retrospective analysis of the morphological characteristics of PAs, aiming to identify their unusual features and prevent misdiagnosis. We discuss the diverse morphological aspects of PAs, with particular emphasis on the challenges associated with their diagnosis.

The purpose. Establishing through a morpho-functional study, which is the most frequent location of metabolically active liver metastases, highlighted by PET-CT correlated with the histological type, in patients with relapses. Materials and methods. The study material was represented by the iconography of 127 patients investigated by PET-CT (Affidea Timișoara), who had presumptive diagnoses of secondary liver determinations. PET-CT investigation reveals the three-dimensional distribution of radioactivity based on annihilation photons emitted by radiotracers labeled with a positron emitter (F18-FDG). The imaging analysis was complemented by the measurement of SUVlbm, the maximum uptake intensity of the radiotracer. Results. The PET-CT examination revealed metabolically active liver lesions in 108 cases. In 95 cases (87.96%), metabolically active multiple nodular lesions were revealed, in different degrees of uptake. Multiple metastases were highlighted at the following levels: RHL - 43 cases; LHL - 21 cases; disseminated - 31 cases. In 13 cases (12.04%), the metastases were solitary, starting point: breast (4xBC), bronchopulmonary (3xBPC), cutaneous malignant melanoma (2xMM), colorectal (3xCRC), pancreatic (1xPC). In the case of solitary liver metastases, the segmental location was as follows: • S-I: 1 case (1 x PC) • S-II: 1 case (1 x BC) • S-III: 2 cases (1 x BC + 1 x BPC) • S-IV: 1 case (1 x BC) • S-VI: 5 cases (2 x BPC + 2 x CRC + 1 x MM) • S-VII: 3 cases (1 x BC + 1 x CRC + 1 x MM). Conclusions. • Most frequently, multiple liver metastases were highlighted at the RHL level - 43 cases (45.26 %). • In 13 cases (12.04%) the lesions were solitary, having the starting point, most frequently, at the breast level - 4 cases (30.77%) • The maximum value SUVlbm=13.7 was highlighted in the case of the single metastasis of MM, located at the S-VI level.