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Ali Seyfoddin
Drug Delivery Research Group, School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand

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Review
Published: 19 July 2021 in Journal of Cannabis Research
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Introduction As the cannabis industry transitions from a black market to a legal market, product development, and methods of extraction have become a focal point. To date, more than thousands of chemical constituents have been identified from the cannabis plant, all of which possess different chemical properties that require different conditions for preservation during drying and extraction. However, scientific publications that explore these areas for the cannabis plant are currently lacking. Method This is a narrative review paper which focuses on critiquing drying and extraction methods of Cannabis sativa L. plant. Relevant keywords such as medicinal cannabis, extraction, solvent, cannabinoids, and terpenes have been searched in PubMed, EMBASE, MEDLINE, Google Scholar, and Cochrane Library (Wiley) databases. Result To find relevant papers for this narrative review, 93 papers have been reviewed. Among them, 12 irrelevant papers were discarded. The excluded papers were either about hemp seed oil or hemp fiber and protein. Based on this review, solvent extraction is the most common method for cannabis plants. Although solventless and hydrodynamic extraction are known for their high yield and feasibility, more investigation is needed in these areas. Regarding the drying process, hang-drying is the most convenient method; however, it may be substituted by freeze-drying in the near future. Discussion This review analyses various drying and extraction processes to guide the selection of suitable methods for various types of cannabis products and applications. This is done by outlining traditional and modern methods of drying techniques, exploring the importance of solvents for extraction, visiting solventless extraction procedures, and finally comparing conventional and alternative methods of extraction. Conclusion In conclusion, based on the current knowledge, using organic solvents is the most convenient method for medicinal cannabis extraction. However, more research is needed for some of the drying and extraction methods. Also, developing a green and sustainable cannabis extraction method should be considered for future studies.

ACS Style

Masoumeh Pourseyed Lazarjani; Owen Young; Lidya Kebede; Ali Seyfoddin. Processing and extraction methods of medicinal cannabis: a narrative review. Journal of Cannabis Research 2021, 3, 1 -15.

AMA Style

Masoumeh Pourseyed Lazarjani, Owen Young, Lidya Kebede, Ali Seyfoddin. Processing and extraction methods of medicinal cannabis: a narrative review. Journal of Cannabis Research. 2021; 3 (1):1-15.

Chicago/Turabian Style

Masoumeh Pourseyed Lazarjani; Owen Young; Lidya Kebede; Ali Seyfoddin. 2021. "Processing and extraction methods of medicinal cannabis: a narrative review." Journal of Cannabis Research 3, no. 1: 1-15.

Journal article
Published: 02 July 2021 in Sustainability
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The purpose of this study was to investigate the perception of in-vitro meat (IVM) among New Zealand consumers and to understand their purchase and consumption behaviour using the Theory of Planned Behaviour framework developed in this study. An online survey questionnaire was created using the Qualtrics software to understand the perception of IVM, based on the conceptual framework. Participants (n = 206) were recruited in this survey, and the data collected were subjected to PLS-PM analysis. The conceptual framework was tested for validity, and Goodness of fit (GoF). The internal validity was assessed using Cronbach’s alpha, KMO value, inter-item correlation values (β-coefficients) and p-values. The findings suggest that variables such as environment and sustainability, health and safety, as well as current purchase and consumption behaviour have a strong relationship and a robust effect on IVM purchase and consumption behaviour. Consumers’ cultural beliefs had minimal influence on IVM purchase likelihood. Results in this study also indicated that most New Zealand consumers had neutral opinions in terms of engaging with IVM.

ACS Style

Maya Malavalli; Nazimah Hamid; Kevin Kantono; Ye Liu; Ali Seyfoddin. Consumers’ Perception of In-Vitro Meat in New Zealand Using the Theory of Planned Behaviour Model. Sustainability 2021, 13, 7430 .

AMA Style

Maya Malavalli, Nazimah Hamid, Kevin Kantono, Ye Liu, Ali Seyfoddin. Consumers’ Perception of In-Vitro Meat in New Zealand Using the Theory of Planned Behaviour Model. Sustainability. 2021; 13 (13):7430.

Chicago/Turabian Style

Maya Malavalli; Nazimah Hamid; Kevin Kantono; Ye Liu; Ali Seyfoddin. 2021. "Consumers’ Perception of In-Vitro Meat in New Zealand Using the Theory of Planned Behaviour Model." Sustainability 13, no. 13: 7430.

Journal article
Published: 29 June 2021 in Respiratory Physiology & Neurobiology
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The yogic pranayama technique of unilateral nostril breathing (UNB) has previously demonstrated improvements in language and anxiety in stroke sufferers, as well as reduced blood pressure and increased heart rate in normal healthy adults. The nose typically passes different amounts of air through each nostril with the greater amount of air passing through the ‘patent’ side, and a lesser amount through the ‘congested’ side. Each side of the nose periodically takes turns at carrying the dominant tidal air flow in what is termed the’ nasal cycle’. The nasal sinuses are a rich source of inhaled nitric oxide, a colourless and odourless gas that acts as a bronchodilator, vasodilator, and neurotransmitter. Nasal derived nitric oxide (NO) may contribute to the benefits attributed to UNB. This investigation seeks to assess the influence the nasal cycle has on inhaled nasopharyngeal NO concentrations during UNB by comparing unobstructed bilateral nostril breathing to patent-side and congested-side UNB in healthy individuals demonstrating a nasal cycle. After determining the patent and congested nasal sides in healthy adult volunteers, and sampling air at both nostrils, nasopharyngeal inhaled NO concentrations were then assessed during normal nasal at-rest tidal breathing during three different nasal breathing states: first both nostrils, then allocated in randomised order, patent side only, and congested side with only UNB. Nasopharyngeal NO concentrations were found to be consistently higher on both exhalation and inhalation during congested side UNB, when compared with either unilateral patent side UNB or breathing through both nostrils.

ACS Style

Tim H.A. Stassen; Jim Bartley; David E. White. Inhaled nasopharyngeal nitric oxide concentrations during unilateral nostril breathing – a pilot study. Respiratory Physiology & Neurobiology 2021, 103734 .

AMA Style

Tim H.A. Stassen, Jim Bartley, David E. White. Inhaled nasopharyngeal nitric oxide concentrations during unilateral nostril breathing – a pilot study. Respiratory Physiology & Neurobiology. 2021; ():103734.

Chicago/Turabian Style

Tim H.A. Stassen; Jim Bartley; David E. White. 2021. "Inhaled nasopharyngeal nitric oxide concentrations during unilateral nostril breathing – a pilot study." Respiratory Physiology & Neurobiology , no. : 103734.

Journal article
Published: 21 June 2021 in IEEE Journal of Translational Engineering in Health and Medicine
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Objective: Fear of dental procedures is a common barrier to effective dental care. A promising technique to overcome dental anxiety is needle-free jet injection, which involves delivering local anaesthetic as a high-speed jet capable of penetrating the oral mucosa without a needle. Previous efforts have used loud, uncontrolled injectors designed for transdermal delivery that have failed to achieve significant uptake in dental practice. Methods: In this work, we present and validate a controllable jet injection device driven by a silent electric motor for the delivery of dental local anaesthetic. The injector includes a novel tubular attachment at its distal end, which allows the delivery to be performed comfortably throughout the mouth. The expected pressure loss resulting from the use of this attachment is analysed. This analysis predicted that a 75 mm long tubular attachment of 0.53 mm radius would result in negligible pressure loss. To validate delivery in human tissue, the injection system was used to perform 18 injections into the mouths of two Thiel-embalmed human cadavers. These injections were visualised using cone-beam computed tomography (CBCT). Results: Benchtop testing of the prototype injector verified the expected pressure loss along the attachment. The CBCT scans demonstrated that the fluid was successfully delivered to the desired locations, adjacent to the root apex of the teeth, at every injection site. Conclusion: These outcomes validate the performance of this novel needle-free injector, demonstrating its potential as a tool to reduce dental anxiety. Clinical and Translational Impact Statement — Our controllable jet injection device overcomes key limitations associated with previous attempts to deliver dental local anaesthetic needle-free. This could greatly reduce barriers to effective dental care.

ACS Style

James W. McKeage; Carolina Loch; Johann Zwirner; Niels Hammer; David E. White; Bryan P. Ruddy; Paul A. Brunton; Andrew J. Taberner. Controllable jet injection of dental local anaesthetic. IEEE Journal of Translational Engineering in Health and Medicine 2021, 9, 1 -1.

AMA Style

James W. McKeage, Carolina Loch, Johann Zwirner, Niels Hammer, David E. White, Bryan P. Ruddy, Paul A. Brunton, Andrew J. Taberner. Controllable jet injection of dental local anaesthetic. IEEE Journal of Translational Engineering in Health and Medicine. 2021; 9 ():1-1.

Chicago/Turabian Style

James W. McKeage; Carolina Loch; Johann Zwirner; Niels Hammer; David E. White; Bryan P. Ruddy; Paul A. Brunton; Andrew J. Taberner. 2021. "Controllable jet injection of dental local anaesthetic." IEEE Journal of Translational Engineering in Health and Medicine 9, no. : 1-1.

Journal article
Published: 04 March 2021 in International Journal of Pharmaceutics
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Drug-eluting bandage contact lenses (BCLs) have been widely studied as an alternative to eye drops due to their ability to increase the drug residence time and bioavailability as well as improve patient compliance. While silicone hydrogel polymers are commonly used in drug-eluting BCLs due to their transparency, mechanical properties and high oxygen permeability, gelatine hydrogels are also clear, flexible and have high oxygen permeability and may therefore be suitable contact lens materials. Moreover, the rheological properties of gelatine hydrogels allow their use as inks in extrusion-based 3D printers, therefore opening the door to a wide range of applications. Drug-loaded gelatine methacryloyl (GelMA) BCLs with different concentrations of poly (ethylene glycol) diacrylate (PEGDA) were prepared using solvent casting and 3D printing. The prepared lenses were characterised for their swelling ratio, in vitro degradation, and drug release properties. The results showed that the incorporation of 10% PEGDA improved the lenses’ resistance to handling and protected them during degradation testing, reduced the swelling ratio and prolonged the release of dexamethasone (DEX). Both techniques were deemed suitable to use in the manufacturing of drug-eluting BCLs noting that the optimal formulation may vary according to the preparation technique utilised.

ACS Style

Ghada Zidan; Carol A. Greene; Alaitz Etxabide; Ilva D. Rupenthal; Ali Seyfoddin. Gelatine-based drug-eluting bandage contact lenses: Effect of PEGDA concentration and manufacturing technique. International Journal of Pharmaceutics 2021, 599, 120452 .

AMA Style

Ghada Zidan, Carol A. Greene, Alaitz Etxabide, Ilva D. Rupenthal, Ali Seyfoddin. Gelatine-based drug-eluting bandage contact lenses: Effect of PEGDA concentration and manufacturing technique. International Journal of Pharmaceutics. 2021; 599 ():120452.

Chicago/Turabian Style

Ghada Zidan; Carol A. Greene; Alaitz Etxabide; Ilva D. Rupenthal; Ali Seyfoddin. 2021. "Gelatine-based drug-eluting bandage contact lenses: Effect of PEGDA concentration and manufacturing technique." International Journal of Pharmaceutics 599, no. : 120452.

Research article
Published: 24 January 2021 in Pharmaceutical Development and Technology
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Conventional methods of probiotics delivery to farmed aquatic animals are not efficient due to loss of probiotic’s viability before the probiotics can reach their site of action. This study aims to develop a microencapsulated probiotic delivery system for black-footed abalone (Haliotis iris). An emulsion technique was used to encapsulate probiotic bacteria within chitosan-coated alginate microparticles (CALG). The efficacy of CALG microparticles in delivering probiotics to abalone was assessed using ex-vivo and in-vivo experiments. Microparticles (113 ± 4 µm) with encapsulation efficiency of more than 75% were developed using an internal gelation formulation approach. The ex-vivo release experiments revealed the lack of probiotic discharge in the first 6h of incubating CALG in seawater followed by a slight bacterial release within the next 20 h. The exposure of CALG microparticles to simulated gastric and intestinal media showed a significantly higher release of encapsulated bacteria in the simulated intestinal medium. The results of feeding trial revealed that the number of probiotic bacteria in probiotic-fed abalone was significantly higher than the one in the control animals. The results suggest that CALG microparticles can be used as a controlled release system for delivering viable probiotic bacteria to the gastrointestinal tract of abalone. Graphical Abstract

ACS Style

Seyedehsara Masoomi Dezfooli; Noemi Gutierrez-Maddox; Andrea C. Alfaro; Ali Seyfoddin. Development of a microencapsulated probiotic delivery system for New Zealand black-footed abalone (Haliotis iris). Pharmaceutical Development and Technology 2021, 26, 390 -402.

AMA Style

Seyedehsara Masoomi Dezfooli, Noemi Gutierrez-Maddox, Andrea C. Alfaro, Ali Seyfoddin. Development of a microencapsulated probiotic delivery system for New Zealand black-footed abalone (Haliotis iris). Pharmaceutical Development and Technology. 2021; 26 (4):390-402.

Chicago/Turabian Style

Seyedehsara Masoomi Dezfooli; Noemi Gutierrez-Maddox; Andrea C. Alfaro; Ali Seyfoddin. 2021. "Development of a microencapsulated probiotic delivery system for New Zealand black-footed abalone (Haliotis iris)." Pharmaceutical Development and Technology 26, no. 4: 390-402.

Journal article
Published: 05 November 2020 in Respiratory Physiology & Neurobiology
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Nasal saline irrigation is frequently utilised in rhinosinusitis management, and after nasal and sinus surgery. Nasal saline irrigation improves mucociliary transport and assists inflammatory mediator and post-surgical debris removal. The aim of this study was to assess the influence different head positions, irrigation inflow nostril, and the nasal cycle have on Neti pot nasal saline volume filling within the nasal passages and maxillary sinuses. Computational fluid dynamics modelling using anatomically correct nasal geometry found only minor difference in nasal cavity volume filling with inflow from either side of the nose however both head position and inflow direction were both found to have a major influence on maxillary sinus volume filling. Computational modelling flow velocity results at the nasopharynx were validated using particle image velocimetry. It was also found that directing irrigation inflow into the patent side of the nose while in the head-back position achieved the highest volume filling of both maxillary sinuses.

ACS Style

Hana Salati; Jim Bartley; Sina G. Yazdi; Mark Jermy; David E. White. Neti pot irrigation volume filling simulation using anatomically accurate in-vivo nasal airway geometry. Respiratory Physiology & Neurobiology 2020, 284, 103580 .

AMA Style

Hana Salati, Jim Bartley, Sina G. Yazdi, Mark Jermy, David E. White. Neti pot irrigation volume filling simulation using anatomically accurate in-vivo nasal airway geometry. Respiratory Physiology & Neurobiology. 2020; 284 ():103580.

Chicago/Turabian Style

Hana Salati; Jim Bartley; Sina G. Yazdi; Mark Jermy; David E. White. 2020. "Neti pot irrigation volume filling simulation using anatomically accurate in-vivo nasal airway geometry." Respiratory Physiology & Neurobiology 284, no. : 103580.

Preprint content
Published: 23 October 2020
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Objective: To assess the influence unilateral nostril breathing has on mean inhaled nasopharyngeal nitric oxide (NO) concentrations compared with unobstructed bilateral nostril breathing in individuals demonstrating a nasal cycle.Methods: After determining the patent and congested nasal sides in healthy adult volunteers (N=10), and sampling air at both nostrils, a small diameter gas sampling tube was passed along the floor of the nose into the volunteer's patent nostril, until it was stationed in the nasopharynx. Nasopharyngeal NO concentrations were then assessed during normal nasal at-rest tidal breathing during three different nasal breathing states: first both nostrils, then allocated in randomised order, patent side only, and congested side only.Results: Nasopharyngeal NO concentrations were consistently higher on both exhalation and inhalation during unilateral congested side nostril breathing, when compared with unilateral patent side nostril breathing, and breathing through both nostrils.Conclusions: During unilateral nostril breathing, inhaled nasopharyngeal NO concentrations are consistently higher on the congested side of the nose.

ACS Style

Tim Stassen; Jim Bartley; Mehrdad Khamooshi; David White. Inhaled nasopharyngeal nitric oxide concentrations during unilateral nostril breathing – a pilot study. 2020, 1 .

AMA Style

Tim Stassen, Jim Bartley, Mehrdad Khamooshi, David White. Inhaled nasopharyngeal nitric oxide concentrations during unilateral nostril breathing – a pilot study. . 2020; ():1.

Chicago/Turabian Style

Tim Stassen; Jim Bartley; Mehrdad Khamooshi; David White. 2020. "Inhaled nasopharyngeal nitric oxide concentrations during unilateral nostril breathing – a pilot study." , no. : 1.

Review
Published: 09 October 2020 in Journal of Cannabis Research
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Background Around 144 cannabinoids have been identified in cannabis plant, among them tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most prominent ones. Because of the legal restrictions on cannabis in many countries, it is difficult to obtain standards to use in research; nonetheless, it is important to develop a cannabinoid quantification technique with pharmaceutical applications for quality control of future therapeutic cannabinoids. Method To find relevant articles for this narrative review paper, a combination of keywords such as medicinal cannabis, analytical, quantification and cannabinoids were searched for in PubMed, EMBASE, MEDLINE, Google Scholar and Cochrane Library (Wiley) databases. Results The most common cannabinoid quantification techniques include gas chromatography (GC) and high-performance liquid chromatography (HPLC). GC is often used in conjunction with mass spectrometry (MS) or flame ionization detection (FID). The major advantage of GC is terpenes quantification however, for evaluating acidic cannabinoids it needs to be derivatised. The main advantage of HPLC is the ability to quantify both acidic and neutral forms of cannabinoids without derivatisation which is often with MS or ultraviolet (UV) detectors. Conclusion Based on the information presented in this review, the ideal cannabinoid quantification method is HPLC- MS/MS for the cannabinoids.

ACS Style

Masoumeh Pourseyed Lazarjani; Stephanie Torres; Thom Hooker; Chris Fowlie; Owen Young; Ali Seyfoddin. Methods for quantification of cannabinoids: a narrative review. Journal of Cannabis Research 2020, 2, 1 -10.

AMA Style

Masoumeh Pourseyed Lazarjani, Stephanie Torres, Thom Hooker, Chris Fowlie, Owen Young, Ali Seyfoddin. Methods for quantification of cannabinoids: a narrative review. Journal of Cannabis Research. 2020; 2 (1):1-10.

Chicago/Turabian Style

Masoumeh Pourseyed Lazarjani; Stephanie Torres; Thom Hooker; Chris Fowlie; Owen Young; Ali Seyfoddin. 2020. "Methods for quantification of cannabinoids: a narrative review." Journal of Cannabis Research 2, no. 1: 1-10.

Review
Published: 20 July 2020 in Polymer Degradation and Stability
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Hydrogels are among the well-liked biomaterials due to their biocompatibility and non-toxic properties which can be used in various applications in the field of engineering and medicine. Hydrogels are hydrophilic components that have the capability to absorb water or biological fluid. Hydrogels can be synthesised by polymer crosslinking. The main objective of this review is to gather information about the various applications of hydrogel. In this review, the properties and applications of various hydrogels such as acrylic acid, acrylamide, and preparation method of these hydrogels using N,N′-methylenebisacrylamide (MBAA-crosslinker), ammonium persulfate (APS-initiator), tetramethylethylenediamine (TEMEDA-catalyst), and Fe+3 (ionic cross linker) are explored and discussed. Additionally, future perspective of such materials in intranasal applications are also considered in this review.

ACS Style

Gangadevi Sennakesavan; Mohammad Mostakhdemin; L.K. Dkhar; Ali Seyfoddin; S.J. Fatihhi. Acrylic acid/acrylamide based hydrogels and its properties - A review. Polymer Degradation and Stability 2020, 180, 109308 .

AMA Style

Gangadevi Sennakesavan, Mohammad Mostakhdemin, L.K. Dkhar, Ali Seyfoddin, S.J. Fatihhi. Acrylic acid/acrylamide based hydrogels and its properties - A review. Polymer Degradation and Stability. 2020; 180 ():109308.

Chicago/Turabian Style

Gangadevi Sennakesavan; Mohammad Mostakhdemin; L.K. Dkhar; Ali Seyfoddin; S.J. Fatihhi. 2020. "Acrylic acid/acrylamide based hydrogels and its properties - A review." Polymer Degradation and Stability 180, no. : 109308.

Journal article
Published: 10 July 2020 in Journal of Orthopaedic Surgery and Research
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Osteotomes are bone cutting tools commonly reused in orthopedic surgical procedures. Despite undergoing rigorous cleaning, visual inspection, and sterilization procedures between every use, the condition of the cutting blade edge is commonly not qualitatively assessed. Subjective feedback from surgeons suggests a large variation in osteotome cutting-edge sharpness is found during use. This study seeks to investigate the retention of osteotome cutting-edge sharpness by comparing the wear resistance of as-supplied, electroless nickel, and titanium nitride coated osteotomes following a series of bone cutting tests. Changes in edge sharpness were assessed using visual inspection, depth penetration testing that quantified change in the blade sharpness index, and scanning electron microscopy visual analysis. Visual inspection of each osteotome blade edge was then compared to qualitative blade sharpness index measurement. After use, no cutting-edge damage or change in blade sharpness was detected by visual examination of all three osteotomes; however, the as-supplied osteotome demonstrated 50% loss of blade sharpness index compared to 30% and 15% reduction for the electroless nickel and titanium nitride coated osteotomes, respectively. This finding was supported by scanning electron microscopy evaluation that found greater mechanical damage had occurred along the cutting edge of the as-supplied osteotome compared to the two coated with wear resistant materials. The rapid loss of blade sharpness found in the as-supplied osteotome supports the degradation in cutting performance frequently reported by surgeons. The findings from this study demonstrate blade sharpness index better detects cutting-edge wear compared to visual inspection. Results from this pilot study also suggest the coating of osteotomes in hard-wearing biocompatible materials assists in retaining cutting-edge sharpness over multiple uses. Further study using a larger sample size is required to validate these findings.

ACS Style

David E. White; Jim Bartley; Christopher Whittington; Lorenzo M. G. Garcia; Kaushik Chand; Celine Turangi. Pilot investigation into osteotome hard surface coating and cutting-edge degradation. Journal of Orthopaedic Surgery and Research 2020, 15, 1 -8.

AMA Style

David E. White, Jim Bartley, Christopher Whittington, Lorenzo M. G. Garcia, Kaushik Chand, Celine Turangi. Pilot investigation into osteotome hard surface coating and cutting-edge degradation. Journal of Orthopaedic Surgery and Research. 2020; 15 (1):1-8.

Chicago/Turabian Style

David E. White; Jim Bartley; Christopher Whittington; Lorenzo M. G. Garcia; Kaushik Chand; Celine Turangi. 2020. "Pilot investigation into osteotome hard surface coating and cutting-edge degradation." Journal of Orthopaedic Surgery and Research 15, no. 1: 1-8.

Preprint content
Published: 09 March 2020
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BackgroundOsteotomes are bone cutting tools commonly reused in orthopedic surgical procedures. Despite undergoing rigorous cleaning, visual inspection and sterilization procedures between every use, the condition of the cutting blade edge is commonly not qualitatively assessed. Subjective feedback from surgeons suggests a large variation in osteotome cutting edge sharpness is found during use. This study seeks to investigate the retention of osteotome cutting-edge sharpness by comparing the wear resistance of as-supplied, electroless nickel, and titanium nitride coated osteotomes following a series of bone cutting tests.MethodsChanges in edge sharpness were assessed using visual inspection, depth penetration testing that quantified change in the blade sharpness index and scanning electron microscopy visual analysis. Visual inspection of each osteotome blade edge was then compared to qualitative blade sharpness index measurement.ResultsAfter use, no cutting-edge damage or change in blade sharpness was detected by visual examination of all three osteotomes however the as-supplied osteotome demonstrated 50% loss of blade sharpness index compared to 30% and 15% reduction for the electroless nickel and titanium nitride coated osteotomes respectively. This finding was supported by scanning electron microscopy evaluation that found greater mechanical damage had occurred along the cutting-edge of the as-supplied osteotome compared to the two coated with wear resistant materials.ConclusionsThe rapid loss of blade sharpness found in the as-supplied osteotome supports the degradation in cutting performance frequently reported by surgeons. The findings from this study demonstrates blade sharpness index better detects cutting edge wear compared to visual inspection. Results from this pilot study also suggest the coating of osteotomes in hard-wearing biocompatible materials assists in retaining cutting edge sharpness over multiple uses. Further study using a larger sample size is required to validate these findings.

ACS Style

David White; Jim Bartley; Christopher Whittington; Lorenzo M. G. Garcia; Kaushik Chand; Celine Turangi. Pilot investigation into osteotome hard surface coating and cutting-edge degradation. 2020, 1 .

AMA Style

David White, Jim Bartley, Christopher Whittington, Lorenzo M. G. Garcia, Kaushik Chand, Celine Turangi. Pilot investigation into osteotome hard surface coating and cutting-edge degradation. . 2020; ():1.

Chicago/Turabian Style

David White; Jim Bartley; Christopher Whittington; Lorenzo M. G. Garcia; Kaushik Chand; Celine Turangi. 2020. "Pilot investigation into osteotome hard surface coating and cutting-edge degradation." , no. : 1.

Review
Published: 26 December 2019 in Antioxidants
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Antioxidants interact with free radicals, terminating the adverse chain reactions and converting them to harmless products. Antioxidants thus minimize the oxidative stress and play a crucial role in the treatment of free radicals-induced diseases. However, the effectiveness of natural and/or synthetic antioxidants is limited due to their poor absorption, difficulties to cross the cell membranes, and degradation during delivery, hence contributing to their limited bioavailability. To address these issues, antioxidants covalently linked with nanoparticles, entrapped in nanogel, hollow particles, or encapsulated into nanoparticles of diverse origin have been used to provide better stability, gradual and sustained release, biocompatibility, and targeted delivery of the antioxidants with superior antioxidant profiles. This review aims to critically evaluate the recent scientific evaluations of nanoparticles as the antioxidant delivery vehicles, as well as their contribution in efficient and enhanced antioxidant activities.

ACS Style

Ibrahim Khalil; Wageeh A. Yehye; Alaitz Etxabide Etxeberria; Abeer A. Alhadi; Seyedehsara Masoomi Dezfooli; Nurhidayatullaili Binti Muhd Julkapli; Wan Jefrey Basirun; Ali Seyfoddin. Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications. Antioxidants 2019, 9, 24 .

AMA Style

Ibrahim Khalil, Wageeh A. Yehye, Alaitz Etxabide Etxeberria, Abeer A. Alhadi, Seyedehsara Masoomi Dezfooli, Nurhidayatullaili Binti Muhd Julkapli, Wan Jefrey Basirun, Ali Seyfoddin. Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications. Antioxidants. 2019; 9 (1):24.

Chicago/Turabian Style

Ibrahim Khalil; Wageeh A. Yehye; Alaitz Etxabide Etxeberria; Abeer A. Alhadi; Seyedehsara Masoomi Dezfooli; Nurhidayatullaili Binti Muhd Julkapli; Wan Jefrey Basirun; Ali Seyfoddin. 2019. "Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications." Antioxidants 9, no. 1: 24.

Review
Published: 02 November 2019 in Respiratory Physiology & Neurobiology
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Nasal saline irrigation is frequently utilised in allergic rhinitis and rhinosinusitis management, and after nasal and sinus surgery. Anatomical modelling, clinical and computational studies guide treatment optimisation. This review offers a comprehensive summary of the modelling methodologies used in previous nasal irrigation studies by undertaking a systematic analysis of anatomical, clinical and computational investigations that assessed nasal saline irrigation using Medline, EMBASE, and Cochrane Review databases. Both procedural and assessment methods were reviewed. It was found that all twenty-four publications reviewed did not discuss the influence of the nasal cycle on internasal geometry and nasal resistance. Cadaver studies misrepresent in vivo nasal geometry. Irrigation pressure and shear forces, which could influence mucociliary transport and postoperative cleaning, were not evaluated. Previous studies focus on irrigation coverage and have not considered the nasal cycle which influences unilateral nasal resistance and thus pressure/ flow relationships and may also increase nasal air-locking. New computational fluid dynamic models could better inform nasal irrigation clinical practice.

ACS Style

Hana Salati; Jim Bartley; David E. White. Nasal saline irrigation - A review of current anatomical, clinical and computational modelling approaches. Respiratory Physiology & Neurobiology 2019, 273, 103320 .

AMA Style

Hana Salati, Jim Bartley, David E. White. Nasal saline irrigation - A review of current anatomical, clinical and computational modelling approaches. Respiratory Physiology & Neurobiology. 2019; 273 ():103320.

Chicago/Turabian Style

Hana Salati; Jim Bartley; David E. White. 2019. "Nasal saline irrigation - A review of current anatomical, clinical and computational modelling approaches." Respiratory Physiology & Neurobiology 273, no. : 103320.

Journal article
Published: 08 June 2019 in Materials Science and Engineering: C
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A chitosan-pectin (CS-PEC) biopolymeric hydrogel wound dressing was investigated for lidocaine delivery. Here we demonstrate for the first time the feasibility of three-dimensional (3D) printed CS-PEC hydrogel incorporating the local anaesthetic drug lidocaine hydrochloride (LDC) as a potential wound dressing candidate. The hydrogels were prepared by physical crosslinking of CS and PEC polysaccharides. The scaffolds were printed using an extrusion-based 3D printer using a mechanical positive displacement dispensing system followed by lyophilisation. The 3D printed hydrogels showed good printability, dimensional integrity and self-adhesion to skin. The high swelling ratio and water absorption of 3D printed hydrogels indicated suitability for absorbing exudates and maintaining a moist wound healing environment. Fourier transform infrared (FTIR) spectroscopy results indicated that the CS-PEC hydrogel was formed by hydrogen bonds. Incorporation of LDC in the hydrogel did not interfere with its functional stability. In vitro drug release studies of LDC over 6 h fitted the Korsmeyer-Peppas model. This work demonstrates the possibility of a 3D printed hydrogel as a suitable candidate for wound dressings.

ACS Style

Jingjunjiao Long; Alaitz Etxabide Etxeberria; Ashveen V. Nand; Craig R. Bunt; Sudip Ray; Ali Seyfoddin. A 3D printed chitosan-pectin hydrogel wound dressing for lidocaine hydrochloride delivery. Materials Science and Engineering: C 2019, 104, 109873 .

AMA Style

Jingjunjiao Long, Alaitz Etxabide Etxeberria, Ashveen V. Nand, Craig R. Bunt, Sudip Ray, Ali Seyfoddin. A 3D printed chitosan-pectin hydrogel wound dressing for lidocaine hydrochloride delivery. Materials Science and Engineering: C. 2019; 104 ():109873.

Chicago/Turabian Style

Jingjunjiao Long; Alaitz Etxabide Etxeberria; Ashveen V. Nand; Craig R. Bunt; Sudip Ray; Ali Seyfoddin. 2019. "A 3D printed chitosan-pectin hydrogel wound dressing for lidocaine hydrochloride delivery." Materials Science and Engineering: C 104, no. : 109873.

Research article
Published: 05 June 2019 in ACS Applied Bio Materials
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This study reports on the fabrication of a controlled release system for the delivery of levonorgestrel (LNG) for long-term contraception. LNG was encapsulated in chemically crosslinked chitosan (CS) microspheres and microspheres presented a spherical geometry with good particle size distribution (polydispersity index (PDI) < 0.1). The LNG-CS microspheres were classified based on their particle size range to <63, 63-125 and 125-300 µm where 125-300 µm were selected to be incorporated into a physically crosslinked and annealed PVA hydrogel matrix to prolong the drug release. PVA concentrations and the annealing treatment influenced the swelling behaviour of PVA hydrogels. Fourier transform infrared (FTIR) spectroscopy indicated that CS was successfully crosslinked through the formation of a Schiff base, PVA hydrogel was formed through hydrogen bonding without reacting with LNG which was only physically entrapped thus maintaining its stability. Differential scanning calorimetry (DSC) showed that freeze-thaw and annealing processes increased the degree of crystallinity in PVA hydrogel. In vitro drug release assessments for all formulations showed zero order without any burst release. Over a period of 100 days, 34, 27 and 21% of LNG were released from the CS-LNG microspheres in the size ranges of <63, 63-125 and 125-300 µm respectively while only 14, 11 and 9 % of LNG was released when the CS-LNG microspheres were incorporated into 10, 15 and 20% PVA hydrogels, respectively. The drug release kinetics exhibited both diffusion- and swelling-controlled mechanisms following Korsmeyer-Peppas model. This work presents a promising delivery system for long-term contraception with controlled zero-order release behaviours.

ACS Style

Jingjunjiao Long; Alaitz Etxabide Etxeberria; Caroline Kornelsen; Ashveen V. Nand; Sudip Ray; Craig R. Bunt; Ali Seyfoddin. Development of a Long-Term Drug Delivery System with Levonorgestrel-Loaded Chitosan Microspheres Embedded in Poly(vinyl alcohol) Hydrogel. ACS Applied Bio Materials 2019, 2, 2766 -2779.

AMA Style

Jingjunjiao Long, Alaitz Etxabide Etxeberria, Caroline Kornelsen, Ashveen V. Nand, Sudip Ray, Craig R. Bunt, Ali Seyfoddin. Development of a Long-Term Drug Delivery System with Levonorgestrel-Loaded Chitosan Microspheres Embedded in Poly(vinyl alcohol) Hydrogel. ACS Applied Bio Materials. 2019; 2 (7):2766-2779.

Chicago/Turabian Style

Jingjunjiao Long; Alaitz Etxabide Etxeberria; Caroline Kornelsen; Ashveen V. Nand; Sudip Ray; Craig R. Bunt; Ali Seyfoddin. 2019. "Development of a Long-Term Drug Delivery System with Levonorgestrel-Loaded Chitosan Microspheres Embedded in Poly(vinyl alcohol) Hydrogel." ACS Applied Bio Materials 2, no. 7: 2766-2779.

Articles
Published: 14 May 2019 in Pharmaceutical Development and Technology
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This study investigated a chemically crosslinked poly(vinyl alcohol) (PVA) hydrogel controlled drug delivery system to deliver the anti-inflammatory drug dexamethasone (DEX). The PVA hydrogels, with different crosslinking densities, were characterized by swelling studies, electron scanning microscopy, viscosity, Fourier transform infrared spectroscopy (FTIR) and in vitro release assessment. Increasing crosslinking density slowed and decreased swelling and water absorption. FTIR analysis suggested DEX has possible interactions with the crosslinker and the PVA polymer. In vitro release of DEX from PVA hydrogels was sustained for 33 days and appeared to fit the Higuchi and Korsmeyer-Peppas models. This work indicates the likelihood of PVA hydrogel as a controlled drug release system for DEX for anti-inflammatory uses.

ACS Style

Jingjunjiao Long; Ashveen Nand; Craig Bunt; Ali Seyfoddin. Controlled release of dexamethasone from poly(vinyl alcohol) hydrogel. Pharmaceutical Development and Technology 2019, 24, 839 -848.

AMA Style

Jingjunjiao Long, Ashveen Nand, Craig Bunt, Ali Seyfoddin. Controlled release of dexamethasone from poly(vinyl alcohol) hydrogel. Pharmaceutical Development and Technology. 2019; 24 (7):839-848.

Chicago/Turabian Style

Jingjunjiao Long; Ashveen Nand; Craig Bunt; Ali Seyfoddin. 2019. "Controlled release of dexamethasone from poly(vinyl alcohol) hydrogel." Pharmaceutical Development and Technology 24, no. 7: 839-848.

Articles
Published: 15 January 2019 in Pharmaceutical Development and Technology
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The aim of this study was to investigate the corneal penetration of brinzolamide nanoemulsions and evaluate their in vitro and ex vivo irritancy potential. Twelve brinzolamide nanoemulsions were prepared by the spontaneous emulsification method and ex vivo permeability studies were conducted using excised bovine corneas fixed onto Franz diffusion cells. To confirm the safety of the formulations for ophthalmic use, preparations were examined for potential ocular irritancy using a cell viability assay on retinal cells, the hen’s egg test-chorioallantoic membrane (HET-CAM) and the bovine corneal opacity-permeability (BCOP) test. Seven brinzolamide nanoemulsions exhibited superior penetration across isolated bovine cornea compared to the marketed brinzolamide suspension. The half maximal inhibitory concentration (IC50) values of various surfactants and oils determined using the sulforhodamine B cell viability assay on retinal cells showed that Transcutol P, Cremophor RH40 and Triacetin were the least toxic excipients and may be safely used in the eye at various concentrations. HET-CAM and BCOP tests revealed that NE6B and NE4C did not results in any irritation and were thus considered safe for ocular use. Our finding suggest that optimized nanoemulsions can be a safe and effective vehicle for ocular delivery of brinzolamide.

ACS Style

Mohammad Mehdi Mahboobian; Ali Seyfoddin; Reza Aboofazeli; Seyed Mohsen Foroutan; Ilva Dana Rupenthal. Brinzolamide–loaded nanoemulsions: ex vivo transcorneal permeation, cell viability and ocular irritation tests. Pharmaceutical Development and Technology 2019, 24, 600 -606.

AMA Style

Mohammad Mehdi Mahboobian, Ali Seyfoddin, Reza Aboofazeli, Seyed Mohsen Foroutan, Ilva Dana Rupenthal. Brinzolamide–loaded nanoemulsions: ex vivo transcorneal permeation, cell viability and ocular irritation tests. Pharmaceutical Development and Technology. 2019; 24 (5):600-606.

Chicago/Turabian Style

Mohammad Mehdi Mahboobian; Ali Seyfoddin; Reza Aboofazeli; Seyed Mohsen Foroutan; Ilva Dana Rupenthal. 2019. "Brinzolamide–loaded nanoemulsions: ex vivo transcorneal permeation, cell viability and ocular irritation tests." Pharmaceutical Development and Technology 24, no. 5: 600-606.

Journal article
Published: 01 September 2018 in International Journal of Pharmaceutics
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Customisation of sustained and controlled release of contraceptives plays a key role in veterinary applications. A biodegradable projectile containing different doses of contraceptive progesterone was prepared using fused deposition modelling 3D printing. Three concentrations of progesterone (2, 5 and 10 % w/w) with polylactic acid was prepared as a 1.75 mm filament by hot melt extrusion. Solvent dissolution tests confirmed the successful incorporation of progesterone in the polymer while microscopic (SEM) studies indicated the drug was melted and thoroughly mixed with the polymer matrix and pore-formation after dissolution. A significant suppression of melting temperature of polymer from 166 to 145 °C was noted by thermal analysis (DSC) studies of the drug loaded systems. Interaction between the contraceptive drug and the polymer via hydrogen bonding was revealed from the spectroscopic (FTIR) studies. In vitro release behaviour was assessed over a five-month period, for 2% and 5% progesterone loaded projectiles release profiles fitted zero order whereas 10% loaded projectiles fitted the Higuchi model. Penetration assessment confirmed the drug loaded PLA projectiles provided sufficient specific kinetic energy required to penetrate thin and medium-thickness skins. This work demonstrates the feasibility of fused deposition modelling 3D printing as suitable process for manufacturing ballistic customised drug delivery devices.

ACS Style

Jingjunjiao Long; Ashveen V. Nand; Sudip Ray; Sam Mayhew; David White; Craig R. Bunt; Ali Seyfoddin. Development of customised 3D printed biodegradable projectile for administrating extended-release contraceptive to wildlife. International Journal of Pharmaceutics 2018, 548, 349 -356.

AMA Style

Jingjunjiao Long, Ashveen V. Nand, Sudip Ray, Sam Mayhew, David White, Craig R. Bunt, Ali Seyfoddin. Development of customised 3D printed biodegradable projectile for administrating extended-release contraceptive to wildlife. International Journal of Pharmaceutics. 2018; 548 (1):349-356.

Chicago/Turabian Style

Jingjunjiao Long; Ashveen V. Nand; Sudip Ray; Sam Mayhew; David White; Craig R. Bunt; Ali Seyfoddin. 2018. "Development of customised 3D printed biodegradable projectile for administrating extended-release contraceptive to wildlife." International Journal of Pharmaceutics 548, no. 1: 349-356.

Review
Published: 19 April 2018 in Reviews in Aquaculture
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The exploitation of wild fisheries has driven the seafood industry to develop more sustainable resources and high‐intensity aquaculture. However, high‐density aquaculture is prone to outbreaks of diseases. The use of chemicals and antimicrobial drugs in aquaculture is common practice, but such chemicals can have serious detrimental environmental impacts and antibiotics may result in bacterial resistance in many species. The development of non‐antibiotic and green strategies, such as using probiotics and immunostimulants, aims for a more sustainable practice for health maintenance in aquaculture. Although the efficacy of such strategies has been demonstrated in cultivations settings, the effective delivery of bioactives remains a challenge. Conventional delivery methods are often ineffective in terms of dosage, stability and species specificity, and can possibly cause widespread environmental contamination. However, recently developed drug delivery systems may provide innovative ways to improve delivery with minimal waste and improved environmental protection. Indeed, such cutting‐edge drug delivery systems have already provided measurable benefits in human medicine over the past two decades. New technologies, such as encapsulation and controlled release systems, can be used readily in scaled‐up operations to improve the delivery of bioactives and ultimately increase production and profitability in aquaculture. This review critically analyses the use of encapsulation technology with a focus on microparticles for delivery of bioactive agents to farmed aquatic animals. This review discusses various potential encapsulation materials, their properties and a range of methods that can be applied and scaled‐up for aquaculture. Finally, practical considerations for designing an efficient delivery system for aquaculture are discussed.

ACS Style

Seyedehsara Masoomi Dezfooli; Noemi Gutierrez-Maddox; Andrea Alfaro; Ali Seyfoddin. Encapsulation for delivering bioactives in aquaculture. Reviews in Aquaculture 2018, 11, 631 -660.

AMA Style

Seyedehsara Masoomi Dezfooli, Noemi Gutierrez-Maddox, Andrea Alfaro, Ali Seyfoddin. Encapsulation for delivering bioactives in aquaculture. Reviews in Aquaculture. 2018; 11 (3):631-660.

Chicago/Turabian Style

Seyedehsara Masoomi Dezfooli; Noemi Gutierrez-Maddox; Andrea Alfaro; Ali Seyfoddin. 2018. "Encapsulation for delivering bioactives in aquaculture." Reviews in Aquaculture 11, no. 3: 631-660.