Fatigue is a common non-motor symptom in Parkinson’s disease (PD), but even so, it may still be underdiagnosed or misdiagnosed in current practice due to its non-specific manifestations. The aims of this study were to investigate the prevalence of fatigue in PD patients compared to healthy controls and to identify the main characteristics and associations of fatigue with other non-motor symptoms and the impact of fatigue on sleep disturbances in Parkinson’s disease. Materials and methods: case–control study in which 131 PD patients and 131 age- and sex-matched controls were enrolled. Main characteristics of fatigue, sleep, and other non-motor symptoms were assessed using specific validated questionnaires. Results: According to the Chalder fatigue scale, fatigue is more prevalent in PD patients (38.16%) compared to healthy controls (26.71%). Fatigue was identified in 46.54% of the PD patients using the Parkinson’s Fatigue Scale (PFS-16). PD patients with fatigue presented a worse motor status, more sleep disturbances (insomnia, daytime sleepiness), a broader spectrum of non-motor symptoms (pain, anxiety, urinary disturbances), worse cognitive performances, a lower level of happiness, and worse quality of life compared to PD patients without fatigue. Conclusion: Fatigue is a common symptom of PD and needs to be assessed, considering its consequences on quality of life. Sleep disturbances have a great influence over fatigue in PD patients.

Introduction: Chronic subdural hematoma is one of the most common and serious conditions associated with head trauma. It is often found in elderly, patients who are currently on anticoagulants or those who suffer from blood coagulation disorders. The modern imagistic methods and the innovative surgical treatments have contributed significantly to the understanding of the pathogenesis of hematoma and the achievement of some exceptional results; therefore, it can be said that chronic subdural hematoma is currently a benign disease, especially involving the elderly. Objective: The purpose of this paper is to identify the etiological and therapeutic peculiarities of the chronic subdural hematoma, from literature data. Methods: We select data from the literature and we included in this paper reviews, case reports, and clinical studies. 30 articles were selected for the papers topic. Discussions: Understanding the pathophysiological mechanism of chronic subdural hema¬toma is imperative, for being able to apply optimal treatment and to reduce the recurrence rate. Surgical treatment is of choice and the operating technique is selected according to the patient’s particularities. Conclusions: Despite the fact that chronic subdural hematoma therapy has improved in recent years, in terms of continuous development of surgical techniques and diagnosis, the best option is still being considered and it is also aimed at decreasing recurrence, which significantly influences the prognosis. Rezumat Introducere: Hematomul subdural reprezintă una dintre cele mai frecvente și grave afecțiuni asociate cu traumatismele craniene. Este adesea întâlnit la vârstnici, la pacienții aflați sub terapie anticoagulantă sau la cei care suferă de tulburări de coagulare. Tehnicile imagistice moderne și tratamentele inovative chirurgicale au contribuit semnificativ la deslușirea patogenezei hematomului și la obținerea unor rezultate excepționale, astfel se poate considera că HSD cronic este, în prezent, o boală benignă, care îi privește, în special, pe vârstnici. Scop/Obiectiv: Scopul acestei lucrări este de a identifica particularitățile etiologice și terapeutice ale pacienților cu hematom subdural cronic, din datele din literatură. Material și metodă: Au fost selectate date din literatură și au fost incluse în acest articol review-urile, prezentările de caz și studiile clinice. Au fost selectate 30 de articole care să fie relevante pentru subiectul lucrării. Discuții: Înțelegerea mecanismelor fiziopatologice ale HSD cronic este imperativă, pentru a putea aplica un tratament optim și pentru a reduce rata de recurență. Tratamentul chirurgical este de elecție în hematomul subdural cronic, tehnica operatorie aleasă fiind selectată în funcție de particularitățile pacientului. Concluzii: În ciuda faptului că terapia hematomului subdural cronic s-a îmbunătățit în ultimii ani, prin prisma dezvoltării continue a tehnicilor chirurgicale și a diagnosticului, încă se analizează cea mai bună opțiune și, de asemenea, se urmărește scăderea recurenței, care influențează semnificativ prognosticul pacienților.