Syed Sikandar Shah

Dr. Syed Sikandar Shah

orcid

Research Focus & Metrics

Academic Career Length

7Years (2020-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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26 November 2025 in BioMedInformatics
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Journal Article
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Aftab AlamAftab Alam
Aftab Alam
SSSyed Sikandar Shah
Syed Sikandar Shah
SRSyed Arman Rabbani
Syed Arman Rabbani
Mohamed El-TananiMohamed El-Tanani
Mohamed El-Tanani
Artificial Intelligence (AI) is reshaping pharmacy practice by enhancing decision-making, personalizing therapy, and improving medication safety. AI applications now span drug discovery, clinical decision support, and adherence monitoring. This narrative review explores key innovations, practical applications, and the implications of AI integration in pharmacy practice, with a focus on emerging tools, pharmacist roles, and ethical considerations. The review was conducted using literature from PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar. Thematic synthesis included AI-based drug interaction checkers, Clinical Decision Support Systems (CDSS), telepharmacy, pharmacogenomics, and predictive analytics. AI enhances clinical decision-making, reduces medication errors, and supports precision medicine. AI tools support pharmacists and healthcare professionals in optimizing care. However, data privacy, algorithmic bias, and workflow integration continue to pose challenges. AI holds transformative potential in pharmacy, though its integration requires overcoming ethical and workflow-related challenges. Ethical and regulatory vigilance, coupled with pharmacist training and interdisciplinary collaboration, is essential to realize the full potential of AI.

15 July 2020 in PLOS ONE
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SSSyed Sikandar Shah
Syed Sikandar Shah
AAAbdikarim Abdi
Abdikarim Abdi
BÖBarçin Özcem
Barçin Özcem
BBBilgen Basgut
Bilgen Basgut
Despite the presence of effective strategies and standard guidelines for the prevention of deep vein thrombosis (DVT), a considerable proportion of patients at risk of developing thromboembolism did not receive prophylaxis during hospitalization, while others received it irrationally, thus led to unwanted side effects. This study aimed to evaluate the current thromboprophylaxis practice and management of hospitalized patients at risk of developing DVT, along with the assessment of health care providers (HCPs) knowledge, and attitudes regarding DVT prevention. An observational study was conducted in the general wards of two leading tertiary university hospitals in Northern Cyprus in which patients from multiple clinics were enrolled to investigate the rational use of DVT prophylaxis using the Caprini risk assessment tool. Patients were also followed for possible complications two weeks post-hospitalization. A cross-sectional study followed to assess the knowledge and attitude of HCPs regarding DVT risks and prophylaxis. Of the 180 patients enrolled, 47.7% were identified as irrationally managed, 52.3% were identified as rationally managed, 77.8% of patients were identified as having a high level of risk. Notably, Four of thirteen patients who received more thromboprophylaxis developed minor complications. Additionally, 73.3% of nurses had not received DVT education. Furthermore, more than 50% of physicians and nurses achieved a low knowledge score for DVT risks and prophylaxis. A high degree of irrationality in the administration of thromboprophylaxis therapy to hospitalized patients was observed. The overall scores for HCPs indicated insufficient knowledge of DVT risk assessments and prophylaxis.

21 January 2026 in Pharmaceutics
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NMNizar Muhammad
Nizar Muhammad
SSSyed Sikandar Shah
Syed Sikandar Shah
ABAshfaq Bukhari
Ashfaq Bukhari
JAJamil Ahmed
Jamil Ahmed
SUShahnaz Usman
Shahnaz Usman
MAMuhammad Junaid Asghar
Muhammad Junaid Asghar
Background: Combating antimicrobial resistance and developing dressings that match all aspects of wound healing will always be challenging. Methods: In this study, hydrogel membranes composed of sodium alginate (SA), polyvinyl alcohol (PVA), and Pluronic-f-127 (F-127) loaded with colistin (C) were formulated. The formulations were divided into two groups: group 1 (SA-PVA-C) and group 2 (SA-PVA-F127-C). Results: The membranes were characterized using multiple techniques, which confirmed component compatibility, physical cross-linking, an amorphous structure, and suitable surface morphology with acceptable porosity. Mechanical testing showed that both groups were suitable for wound-dressing applications. Differences in drug release across media (water, normal saline, and phosphate) were non-significant (p value > 0.05). Drug-loaded membranes (n = 3) from both groups showed antibacterial activity against multidrug-resistant Gram-negative Pseudomonas aeruginosa (ZOI = 20.33 ± 2.51 mm, 21.66 ± 2.08 mm). Conclusions: Overall, the developed hydrogel membranes (both group 1 and group 2) demonstrated promising in vitro potential as colistin delivery systems for wound infection management.

18 March 2025 in Journal of Computational Biophysics and Chemistry
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Journal Article
Closed access
RSRaheela Sarwar
Raheela Sarwar
BABashir Ahmad
Bashir Ahmad
SSSyed Sikandar Shah
Syed Sikandar Shah
SHSaid Hassan
Said Hassan
AUAmin Ullah
Amin Ullah

22 February 2024
Verified
Journal Article
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SBSudhair Abbas Bangash
Sudhair Abbas Bangash
DFDarlington David Faijue
Darlington David Faijue
SSSyed Sikandar Shah
Syed Sikandar Shah
SASana Ahmad
Sana Ahmad
IPIliya Petkov
Iliya Petkov
Ganesh E.N.Ganesh E.N.
Ganesh E.N.
Background: Parkinson's disease (PD) is a multifaceted neurodegenerative condition manifesting in adulthood, characterized by a spectrum of motor and non-motor symptoms. The alteration in the voice of individuals with PD can significantly impact their communication dynamics with the surrounding environment, influencing the perceptions of those around them. Objective: This study aims to assess the perception of vocal difficulties in individuals with Parkinson's disease from the perspective of their socio-family environment. Methodology: A cross-sectional descriptive observational study was conducted involving 17 relatives of individuals with Parkinson's disease, comprising family members and friends acting as primary caregivers in the city of Lahore. Data were collected through in-person surveys, utilizing an adapted version of the VHI-30 questionnaire. Results: Of the participants, 71.2% were aged over 40, with 76.5% being women, and spending more than 5 hours daily with their family members afflicted by PD. A significant 76.4% acknowledged a specific impact related to vocal difficulties in their PD-affected family member, considering functional, physical, and emotional criteria. Within this group, 29.4% reported mild to moderate difficulties, while 47% reported severe to very severe difficulties. Conclusion: Family members and caregivers exhibit varying degrees of perception regarding the vocal challenges faced by individuals with Parkinson's disease. Recognizing the impact on functional, physical, and emotional aspects is crucial. Inclusive therapeutic interventions that involve the socio-family environment are essential for effectively addressing the challenges posed by the disease.

6 February 2024
Verified
Journal Article
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SBSudhair Abbas Bangash
Sudhair Abbas Bangash
SSSyed Sikandar Shah
Syed Sikandar Shah
SHSidra Hassan
Sidra Hassan
MAMoktadirul Alam
Moktadirul Alam
MUMuhammad Umar
Muhammad Umar
TRTariq Rafique Rana
Tariq Rafique Rana
Introduction: Malnutrition in the context of Parkinson's disease involves both excess and deficiency, with deficiency recognized as a prominent global cause of immunodeficiency. Various risk factors, including weight loss, levodopa treatment duration, anxiety, and symptoms related to dysautonomia, contribute to malnutrition in Parkinson's patients. Objective: This study aims to delineate the impact of nutritional interventions on individuals with neurodegenerative Parkinson's disease. Methodology: Conducted as a retrospective descriptive bibliographic review, the study involves a comprehensive search and analysis of original scientific articles in Spanish and English. Medical information databases such as PubMed, Web of Science, BVS, Scholar, Medline, SciELO, etc., were utilized for article selection. Results: Out of 37 screened scientific articles, nine high-level evidence surveys were included, following predefined inclusion and exclusion criteria. The nutritional approach to Parkinson's involves guided diets tailored to the patient's nutritional status and disease progression. The Mediterranean diet emerges as a well-supported option for nutritional support in Parkinson's, along with recommendations for diet modification in the consistency of both liquids and solids. Conclusion: This review underscores the importance of addressing malnutrition in Parkinson's disease through a targeted nutritional approach. Guided diets, especially those aligned with the principles of the Mediterranean diet, are recognized as valuable strategies. Modification of diet consistency, considering the progression of the disease, further adds to the nuanced nutritional management of Parkinson's patients.